评估肿瘤微环境与预后知识网络的时空分布，探索新的研究热点和趋势。收录了 1999 年 1 月至 2022 年 4 月 Web of Science 杂志上有关肿瘤微环境和预后的文章和评论。我们使用CiteSpace和VOSviewer软件来分析由期刊、机构、国家、作者和关键词组成的知识网络。 Frontiers in Immunology、Cancers 和 Frontiers in Oncology 发表了该领域超过 10% 的文章。中国和美国贡献的文章最多。复旦大学和中山大学是最活跃的院校。该领域的作者密切合作；张伟和道格拉斯做出了突出的贡献。肿瘤微环境与预后的三个主要研究领域是微环境、预后和免疫治疗。直到2020年，主要关键词是内皮生长因子和粘附。近三年使用了生存分析、免疫细胞浸润、预测模型。可见，该领域的关注重点已从肿瘤细胞行为和直接相关分子转向预后预测和微环境中的非肿瘤细胞。未来的研究趋势可能是研究肿瘤微环境的变化来预测预后并指导治疗。使用VOSviewer、CiteSpace和Microsoft Excel 2019对肿瘤环境和预后的研究进行全面的可视化分析，为研究人员提供有价值的参考资料。

To evaluate the temporal and spatial distribution of the knowledge network about tumor microenvironment and prognoses and explore new research hot spots and trends. Articles and reviews on tumor microenvironment and prognoses in the Web of Science journal from January 1999 to April 2022 were included. We used the CiteSpace and VOSviewer software to analyze the knowledge network composed of journals, institutions, countries, authors, and keywords. Frontiers in Immunology, Cancers, and Frontiers in Oncology have published more than 10% of articles in this field. China and the United States have contributed the most articles. Fudan University and Sun Yat-Sen University are the most active institutions. The authors in this field work closely; Zhang Wei and Douglas have made outstanding contributions. The three main research areas of tumor microenvironment and prognoses are microenvironment, prognosis, and immunotherapy. Until 2020, the main keywords were endothelial growth factor and adhesion. In the past three years, survival analysis, immune cell infiltration, and prediction model have been used. It can be seen that the focus in this field has shifted from tumor cell behavior and directly related molecules to prognosis prediction and non-tumor cells in the microenvironment. The future research trend may be to study the changes in the tumor microenvironment to predict the prognosis and guide the treatment. VOSviewer, CiteSpace, and Microsoft Excel 2019 were used to conduct a comprehensive visual analysis of the research on tumor environment and prognoses and provide valuable reference materials for researchers.