母亲比父亲更容易传播阿尔茨海默病 (AD)。女性长寿以外的因素可能也促进了 AD 的母体传播。其中包括 X 染色体、线粒体 DNA 和 AD 合并症，尤其是抑郁症。最近的一项研究将线粒体 SNP rs2853499 与 AD 相关。我们使用英国生物银行 (UKBB) 数据来研究线粒体 SNP rs2853499 与 AD 的关系。为了识别 AD 病例，我们使用 ICD10 代码 G30.9。数据处理是在西奈山伊坎医学院的 Minerva（一台装有 Centos 7.6 的 Linux 大型机）上进行的。我们使用全基因组关联分析工具集 PLINK 来分析 UKB22418 线粒体硬调用染色体文件。 在 953 例 AD 病例中，男性 493 例（51.7%），女性 460 例（48.3%）。母亲传播 AD 的可能性是父亲的两倍。我们发现，在 AD 患者中，22.3% (n=201) 携带 SNP rs2853499 的 A 等位基因，77.7% (n=700) 携带 G 等位基因。在没有 AD 的个体中，22.2% (n=10,7726) 携带 SNP rs2853499 的 A 等位基因，77.8% (n=378,535) 携带 G 等位基因。这种差异并不显着（p=0.91，双尾 Fisher 精确检验）。因此，线粒体 SNP rs2853499 以外的因素可能会促进 AD 的母体传播。我们得出结论，母亲的抑郁症（一种多基因疾病）很可能是母亲传播 AD 的几率是父亲两倍的基础。版权© 2023，国际抗癌研究所（George J. Delinasios 博士），保留所有权利。

Mothers transmit Alzheimer's disease (AD) more frequently than fathers. Factors other than female longevity may be at work to promote maternal transmission of AD. Among these are the X chromosome, mitochondrial DNA, and AD comorbidities, especially depression. A recent study associated mitochondrial SNP rs2853499 with AD.We used UK Biobank (UKBB) data to investigate the relation of mitochondrial SNP rs2853499, with AD. To identify cases of AD we used ICD10 code G30.9. Data processing was performed on Minerva, a Linux mainframe with Centos 7.6, at the Icahn School of Medicine at Mount Sinai. We used PLINK, a whole-genome association analysis toolset, to analyze the UKB22418 mitochondrial hard-called chromosome file.Of 953 AD cases, 493 were male (51.7%) and 460 were female (48.3%). Mothers were twice as likely to transmit AD compared to fathers. We found that in individuals with AD, 22.3% (n=201) carried the A allele of SNP rs2853499, 77.7% (n=700) carried the G allele. In individuals without AD, 22.2% (n=10,7726) carried the A allele of SNP rs2853499, 77.8% (n=378,535) carried the G allele. This difference was not significant (p=0.91, two-tailed Fisher exact test). Therefore, factors other than mitochondrial SNP rs2853499 may be at work to promote maternal transmission of AD.We conclude that depression, a multigenic illness, in the mother is most likely the basis for the fact that mothers transmit AD twice as often as fathers.Copyright © 2023, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.