本研究旨在评估辅助放疗对主要唾液腺恶性肿瘤患者局部控制、无病生存率和总生存率的影响。该研究还旨在提供研究结果，指导临床医生选择合适的辅助放疗候选人并优化这种具有挑战性的疾病的治疗策略。进行了回顾性单中心分析，回顾了 2008 年 11 月期间诊断为主要唾液腺恶性肿瘤的患者的医疗记录2023 年 5 月。纳入标准为组织学证实的恶性肿瘤、原发肿瘤的手术切除、辅助放疗以及临床和随访数据的可用性。使用Kaplan-Meier法进行生存分析，并使用Cox比例风险回归模型评估生存结果。该研究包括37名患有主要唾液腺恶性肿瘤的患者。最常见的部位是腮腺，主要的组织病理学诊断是唾液管癌。辅助放疗通常耐受性良好，最常见的急性毒性是 1-2 级粘膜炎和皮炎。 5年总生存率和无进展生存率分别为93.8%和62.9%。五年局部控制率为89.1%。 12 名患者出现复发，大多数病例在辅助放疗开始后两年内观察到。在 9 名患者中观察到远处转移。这项回顾性分析强调了辅助放疗对主要唾液腺恶性肿瘤的局部控制和生存结果的积极影响。这些发现为现有证据做出了贡献，帮助临床医生做出治疗决策，并有可能为这种挑战性疾病的未来前瞻性研究和治疗指南提供信息。版权所有 © 2023，国际抗癌研究所（George J. Delinasios 博士），All保留权利。

This study aimed to assess the effect of adjuvant radiotherapy on locoregional control, disease-free survival, and overall survival rates in patients with major salivary gland malignancies. The study also aimed to provide findings to guide clinicians in selecting appropriate candidates for adjuvant radiotherapy and optimizing treatment strategies for this challenging disease.A retrospective single-center analysis was conducted, reviewing the medical records of patients diagnosed with major salivary gland malignancies between November 2008 and May 2023. Inclusion criteria were histologically confirmed malignancy, surgical resection of the primary tumor, adjuvant radiotherapy, and availability of clinical and follow-up data. Survival analyses were performed using the Kaplan-Meier method, and Cox proportional hazards regression models were used to assess survival outcomes.The study included 37 patients with major salivary gland malignancies. The most common site was the parotid gland, and the predominant histopathological diagnosis was salivary duct carcinoma. Adjuvant radiotherapy was generally well-tolerated, with the most common acute toxicities being grade 1-2 mucositis and dermatitis. The 5-year overall survival and progression-free survival rates were 93.8% and 62.9%, respectively. Locoregional control rate at five years was 89.1%. Recurrence occurred in 12 patients, with most cases observed within two years from the start of adjuvant radiotherapy. Distant metastasis was observed in nine patients.This retrospective analysis highlights the positive impact of adjuvant radiotherapy on locoregional control and survival outcomes in major salivary gland malignancies. The findings contribute to the existing body of evidence, aiding clinicians in treatment decision-making and potentially informing future prospective studies and treatment guidelines for this challenging disease.Copyright © 2023, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.