通过相分离形成的生物分子凝聚体广泛存在，并在许多生理和病理过程中发挥着关键作用。 cGAS-STING 信号传导功能可检测异常 DNA 信号，从而启动抗感染防御和抗肿瘤免疫。同时，必须仔细调节 cGAS-STING 信号传导以维持免疫稳态。有趣的是，最近令人兴奋的研究表明，生物分子相分离存在，并在 cGAS-STING 信号传导的不同步骤中发挥着重要作用，包括 cGAS 冷凝物、STING 冷凝物和 IRF3 冷凝物。此外，还提出了几种细胞内和细胞外因子来调节 cGAS-STING 信号传导中的凝聚物。这些研究揭示了 cGAS-STING 信号传导的新激活和调节机制，并为药物发现提供了新的机会。在这里，我们总结了 cGAS-STING 信号相分离的最新进展以及针对这些先天免疫凝聚物的潜在药物的开发。© 2023。高等教育出版社。

Biomolecular condensates formed by phase separation are widespread and play critical roles in many physiological and pathological processes. cGAS-STING signaling functions to detect aberrant DNA signals to initiate anti-infection defense and antitumor immunity. At the same time, cGAS-STING signaling must be carefully regulated to maintain immune homeostasis. Interestingly, exciting recent studies have reported that biomolecular phase separation exists and plays important roles in different steps of cGAS-STING signaling, including cGAS condensates, STING condensates, and IRF3 condensates. In addition, several intracellular and extracellular factors have been proposed to modulate the condensates in cGAS-STING signaling. These studies reveal novel activation and regulation mechanisms of cGAS-STING signaling and provide new opportunities for drug discovery. Here, we summarize recent advances in the phase separation of cGAS-STING signaling and the development of potential drugs targeting these innate immune condensates.© 2023. Higher Education Press.