结直肠癌 (CRC) 是美国 (US) 癌症相关死亡的第二大原因；然而，关于死于结直肠癌的患者死亡地点的数据有限。我们研究了美国 CRC 死亡患者的死亡地点和决定因素的趋势。我们利用疾病控制和预防中心流行病学研究广泛在线数据数据库提取全国范围内有关 CRC 潜在死因的数据。采用多项 Logistic 回归来评估临床社会人口学特征与死亡地点之间的关联。2003 年至 2019 年，有 850,750 例因 CRC 死亡。医院、疗养院或门诊设施/急诊室的死亡人数逐渐减少随着时间的推移，家庭和临终关怀中心的死亡人数不断增加。与白人死者相比，黑人、亚洲人和美洲印第安人/阿拉斯加原住民死者在家中和临终关怀中心死亡的可能性低于医院。与在医院相比，教育程度较低的人在家中或临终关怀机构死亡的风险也较低。死于结直肠癌的患者的死亡地点从机构化环境逐渐转移到家庭和临终关怀机构，这是一个有希望的趋势，反映了优先顺序医疗保健提供者对临终关怀的患者目标。然而，在家中和临终关怀机构死亡方面存在社会人口统计学差异，这强调需要采取政策干预措施来减少 CRC 临终关怀中的健康不平等。© 2023。外科肿瘤学会。

Colorectal cancer (CRC) is the second leading cause of cancer-related mortality in the United States (US); however, there are limited data on location of death in patients who die from CRC. We examined the trends in location of death and determinants in patients dying from CRC in the US.We utilized the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research database to extract nationwide data on underlying cause of death as CRC. A multinomial logistic regression was performed to assess associations between clinico-sociodemographic characteristics and location of death.There were 850,750 deaths due to CRC from 2003 to 2019. There was a gradual decrease in deaths in hospital, nursing home, or outpatient facility/emergency department over time and an increase in deaths at home and in hospice. Relative to White decedents, Black, Asian, and American Indian/Alaska Native decedents were less likely to die at home and in hospice compared with hospitals. Individuals with lower educational status also had a lower risk of dying at home or in hospice compared with in hospitals.The gradual shift in location of death of patients who die of CRC from institutionalized settings to home and hospice is a promising trend and reflects the prioritization of patient goals for end-of-life care by healthcare providers. However, there are existing sociodemographic disparities in access to deaths at home and in hospice, which emphasizes the need for policy interventions to reduce health inequity in end-of-life care for CRC.© 2023. Society of Surgical Oncology.