癌症一直对人类健康构成重大威胁，由于传统疗法的局限性，促使人们对新的治疗策略进行广泛的研究。饥饿疗法（ST）通过针对癌细胞增殖的主要能源葡萄糖而引起了相当大的关注。葡萄糖氧化酶 (GOx) 是一种促进葡萄糖消耗的催化剂，已成为 ST 的关键治疗剂。然而，单独使用单一 ST 很难完全抑制肿瘤生长，因此需要开发协同治疗方法。金属催化剂具有类似酶的功能，可以作为载体，能够与GOx结合，实现多种肿瘤治疗。然而，确保酶活性在正常组织中保留并在肿瘤内特异性激活是一个严峻的挑战。纳米递送系统通过提高治疗剂的稳定性和实现控制释放来提供增强治疗效果的潜力。本综述主要关注GOx与金属催化剂联合协同肿瘤治疗机制的最新进展。此外，它还讨论了为不同载体类别的协同治疗而设计的各种纳米颗粒（NP）结构。最后，本综述总结了基于 GOx-金属催化剂的纳米颗粒 (G-M)，并深入探讨了与 G-M 治疗、输送设计和氧气 (O2) 供应相关的挑战。© 2023。作者。

Cancer has always posed a significant threat to human health, prompting extensive research into new treatment strategies due to the limitations of traditional therapies. Starvation therapy (ST) has garnered considerable attention by targeting the primary energy source, glucose, utilized by cancer cells for proliferation. Glucose oxidase (GOx), a catalyst facilitating glucose consumption, has emerged as a critical therapeutic agent for ST. However, mono ST alone struggles to completely suppress tumor growth, necessitating the development of synergistic therapy approaches. Metal catalysts possess enzyme-like functions and can serve as carriers, capable of combining with GOx to achieve diverse tumor treatments. However, ensuring enzyme activity preservation in normal tissue and activation specifically within tumors presents a crucial challenge. Nanodelivery systems offer the potential to enhance therapy effectiveness by improving the stability of therapeutic agents and enabling controlled release. This review primarily focuses on recent advances in the mechanism of GOx combined with metal catalysts for synergistic tumor therapy. Furthermore, it discusses various nanoparticles (NPs) constructs designed for synergistic therapy in different carrier categories. Finally, this review provides a summary of GOx-metal catalyst-based NPs (G-M) and offers insights into the challenges associated with G-M therapy, delivery design, and oxygen (O2) supply.© 2023. The Author(s).