原发性垂体 T 淋巴细胞淋巴瘤是一种罕见的临床实体。一名 45 岁女性因头痛、左眼视力模糊、复视、眼肌麻痹和上睑下垂就诊。大脑磁共振成像显示鞍区肿块很可能与垂体大腺瘤一致。实验室评估发现继发性甲状腺功能减退症、继发性肾上腺皮质功能不全和高催乳素血症。通过经蝶切除术切除肿块，随后的免疫表型分析显示 T 细胞淋巴母细胞淋巴瘤。二次检查证实淋巴瘤局限于中枢神经系统。切除后，患者的头痛有所改善，但她出现持续性视力缺陷以及第 III、IV 和 VI 脑神经麻痹。化疗方案包括大剂量甲氨蝶呤，随后环磷酰胺、硫酸长春新碱、盐酸阿霉素（阿霉素）、地塞米松（环磷酰胺、美司钠、硫酸长春新碱、盐酸阿霉素、地塞米松）和甲氨蝶呤/阿糖胞苷交替循环。自从接受化疗以来，麻木、眼睑下垂、左眼眶压力和头痛都有所改善。该病例仅代表第八例 T 细胞原发性垂体淋巴瘤，也是接受诊断的最年轻的患者。© 作者 2023。由牛津大学出版社代表内分泌学会出版。

Primary pituitary T-lymphoblastic lymphoma is a rare clinical entity. A 45-year-old woman presented with headache, left-eye blurry vision, diplopia, ophthalmoplegia, and ptosis. Magnetic resonance imaging of the brain showed a sellar mass most likely consistent with a pituitary macroadenoma. Laboratory evaluation disclosed secondary hypothyroidism, secondary adrenal insufficiency, and hyperprolactinemia. The mass was removed by transsphenoidal resection, and subsequent immunophenotyping revealed T-cell lymphoblastic lymphoma. Secondary workup confirmed lymphomatous confinement to the central nervous system. Following resection, the patient's headaches improved, but she experienced persistent visual deficits and palsies of cranial nerves III, IV, and VI. The chemotherapy regimen consisted of high-dose methotrexate, followed by alternating cycles of cyclophosphamide, vincristine sulfate, doxorubicin hydrochloride (Adriamycin), dexamethasone (cyclophosphamide, mesna, vincristine sulfate, doxorubicin hydrochloride, dexamethasone), and methotrexate/cytarabine. Since receiving chemotherapy, there has been an improvement in numbness, ptosis, left orbital pressure, and headaches. This case represents only the eighth example of T-cell primary pituitary lymphoma, and the youngest patient to receive the diagnosis.© The Author(s) 2023. Published by Oxford University Press on behalf of the Endocrine Society.