自噬是溶酶体消除进入细胞的细胞器、细胞质位点和病原微生物的过程。这个过程与细胞死亡调节和细胞存活机会的增加有关。自噬参与多种疾病（克罗恩病、癌症、动脉粥样硬化等）的发生发展。由于这些原因，建立参与自噬调节的分子靶点以及介导其参与发病机制的因素具有重要意义。该综述描述了自噬调节中涉及的潜在分子机制、其对健康有机体中重要细胞活动的贡献以及病理学。版权所有 ® 2023 国立研究大学高等经济学院。

Autophagy is the process of lysosomal elimination of the cell organelles, cytoplasmic sites, and pathogenic microorganisms that enter the cell. This process is associated with both cell death regulation and an increase in cell survival chances. Autophagy is involved in the development of various diseases (Crohn disease, cancer, atherosclerosis, etc.). For these reasons, it is of significant interest to establish the molecular targets involved in autophagy regulation and the factors that mediate its participation in pathogenesis. The review describes the potential molecular mechanisms involved in the regulation of autophagy, its contribution to the vital cell activity in a healthy organism, and pathologies.Copyright ® 2023 National Research University Higher School of Economics.