海洋生物资源因其独特的理化性质和显着的生物活性，正在成为生产保健品、食品、化妆品的重要原料来源。海参体壁中胶原蛋白约占70%，其水解产生具有多种生物功能的小分子胶原蛋白多肽，如抗癌、降压、增强免疫、增强记忆、修复软骨组织等作用。值得注意的是，海参多肽与抗癌治疗相结合的潜力已引起广泛关注。确定海参多肽的组成和结构并探索其构效关系，将有助于深入了解其多样化的生物活性，为海参多肽的开发利用提供科学依据。因此，本文重点对不同分子量的海参多肽的氨基酸结构和活性进行综述。本研究还概述了各种海参多肽的生物活性，旨在为其开发建立科学依据。版权所有 © 2023 Shou、Feng、Lu、Mao、Huang、Su、Guo 和 Huang。

Owing to their unique physical and chemical properties and remarkable biological activities, marine biological resources are emerging as important sources of raw materials for producing health products, food, and cosmetics. Collagen accounts for approximately 70% of the sea cucumber body wall, and its hydrolysis produces small-molecule collagen polypeptides with diverse biological functions, such as anticancer, antihypertensive, immune-enhancing, memory-enhancing, and cartilage tissue repairing effects. Notably, the potential of sea cucumber polypeptides in combination with anticancer therapy has garnered considerable attention. Determining the composition and structure of sea cucumber polypeptides and exploring their structure-activity relationships will aid in obtaining an in-depth understanding of their diverse biological activities and provide scientific insights for the development and utilization of these polypeptides. Therefore, this review focuses on the amino acid structures and activities of sea cucumber polypeptides of varying molecular weights. This study also provides an overview of the biological activities of various sea cucumber polypeptides and aims to establish a scientific basis for their development.Copyright © 2023 Shou, Feng, Lu, Mao, Huang, Su, Guo and Huang.