白藜芦醇通过 RBM15 调节 CCNB1 的稳定性来影响 ccRCC 细胞衰老和巨噬细胞极化。
Resveratrol affects ccRCC cell senescence and macrophage polarization by regulating the stability of CCNB1 by RBM15.
发表日期：2023 Nov 01
作者：
Zhi Chen, Chang Liu, Tao Ye, Yucong Zhang, Yuan Chen
来源：
Epigenetics & Chromatin
摘要：
目的：本研究旨在探讨白藜芦醇对透明细胞肾细胞癌的治疗作用。材料
Aim: The present study sought to investigate the therapeutic effect of resveratrol on clear cell renal cell carcinoma. Materials & methods: Cell Counting Kit-8 and 5-ethynyl-2'-deoxyuridine assays were used to verify the cell proliferation. Transwell, real-time quantitative transcription PCR, western blot and β-galactosidase staining were used to verify the migration, macrophage polarization and senescence. The tumor inhibitory effect of resveratrol on clear cell renal cell carcinoma was verified in vivo. Results: This study confirmed that resveratrol could affect the stability of CCNB1 mRNA mediated by RBM15 and inhibit the cancer process by inhibiting the expression of EP300/CBP from the perspective of cell senescence. Conclusion: Resveratrol is able to treat clear cell renal cell carcinoma through RBM15-induced cell senescence.