根据最近的几项研究，坏死性凋亡是一种类似于坏死的程序性细胞死亡，现在已知它依赖于与细胞凋亡不同的分子机制。许多研究报告了坏死性凋亡对人类疾病的可能影响，并得出了其在各种疾病（包括肝病、肾损伤、癌症等）的病理生理学中的关键作用。纤维化是几种慢性炎症性疾病最常见的终末期病理级联。在这篇综述中，我们解释了坏死性凋亡和纤维化的影响，坏死性凋亡已被证明是其中的一个促成因素。我们还回顾了坏死性凋亡抑制剂以及它们如何应用于纤维化模型。本综述有助于阐明坏死性凋亡在纤维化中的作用，并将鼓励临床努力针对这一程序性细胞死亡途径。© 2023。作者。

Necroptosis, a type of programmed cell death that resembles necrosis, is now known to depend on a different molecular mechanism from apoptosis, according to several recent studies. Many efforts have reported the possible influence of necroptosis in human disorders and concluded the crucial role in the pathophysiology of various diseases, including liver diseases, renal injuries, cancers, and others. Fibrosis is the most common end-stage pathological cascade of several chronic inflammatory disorders. In this review, we explain the impact of necroptosis and fibrosis, for which necroptosis has been demonstrated to be a contributing factor. We also go over the inhibitors of necroptosis and how they have been applied to fibrosis models. This review helps to clarify the role of necroptosis in fibrosis and will encourage clinical efforts to target this pathway of programmed cell death.© 2023. The Author(s).