牙源性肿瘤是家畜中罕见的肿瘤，大多为孤立性和局部浸润性，但很少发生转移。我们报告了一只 13 岁绝育公猫出现下颌牙龈新生的病例。计算机断层扫描显示不规则的新生结构，具有明显的对比后增强，与切牙和下颌联合的溶解有关。组织学上，口腔粘膜和下颌骨被肿瘤浸润，该肿瘤由牙源性上皮混合群与牙源性外间充质束混合组成，多灶性与硬组织沉积相关。纺锤体细胞成分已转移至右下颌淋巴结。上皮成分对细胞角蛋白 (CK) 5/6、CK 14、全细胞角蛋白 (CK AE1/AE3) 和 p63 具有免疫反应性；外间充质成分呈波形蛋白阳性。最终诊断为成釉细胞纤维牙肉瘤，伴有骨侵犯和淋巴结转移。研究结果表明了这种罕见肿瘤的转移潜力。版权所有 © 2023 Elsevier Ltd. 保留所有权利。

Odontogenic tumours are uncommon neoplasms in domestic animals, mostly solitary and locally infiltrative, but rarely metastatic. We report the case of a 13-year-old neutered male cat presented with a mandibular gingival neoformation. A computed tomography scan revealed an irregular neoformation with marked post-contrast enhancement, associated with lysis of the incisive bone and mandibular symphysis. Histologically, the oral mucosa and mandibular bone were infiltrated by a neoplasm consisting of a mixed population of odontogenic epithelium admixed with bundles of odontogenic ectomesenchyme, multifocally associated with hard tissue deposition. A spindloid cell component had metastasized to the right mandibular lymph node. The epithelial component was immunoreactive for cytokeratins (CK) 5/6, CK 14, pancytokeratin (CK AE1/AE3) and p63; the ectomesenchymal component was vimentin positive. A final diagnosis of ameloblastic fibro-odontosarcoma with bone invasion and lymph node metastasis was made. The findings indicate the metastatic potential of this rare tumour.Copyright © 2023 Elsevier Ltd. All rights reserved.