感染仍然是血液系统恶性肿瘤儿童死亡的一个重要原因。镰刀菌病是一种相对罕见的机会性感染，病程危险且预后不良。下面，我们描述了一名 15 岁患者的致命病程，该患者患有 ALL 骨髓和睾丸复发合并多系统尖孢镰刀菌感染并伴有暴发性演变。尽管采取了积极的治疗，包括多药抗真菌治疗和手术清创，患者还是死于这种疾病。对文献进行了回顾，并强调了早期发现镰刀菌症状的必要性。该病例鼓励进一步研究该疾病的预防和治疗。版权所有 © 2023 日本化疗学会、日本传染病协会和日本感染预防控制学会。由爱思唯尔有限公司出版。保留所有权利。

Infections are still a significant cause of mortality in children with hematologic malignancies. Fusariosis is a relatively rare and opportunistic infection, which may present dangerous course and a poor prognosis. Below, we describe the fatal course of a 15-years old patient with a combined bone marrow and testicular relapse of ALL and multisystemic Fusariosis oxysporum infection with fulminant evolution. Despite aggressive therapy, which included multiagent antifungal treatment and surgical debridement, patient succumbed to the disease. The review of the literature was conducted and the need for early detection of fusarium symptoms was emphasized. The case encourages further research in the prevention and treatment of the illness.Copyright © 2023 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control. Published by Elsevier Ltd. All rights reserved.