制备了一种先进形式的具有核壳结构的磷酸锌/羟基磷灰石纳米棒（ZPh/HPANRs），然后与壳聚糖聚合物链杂交，制成安全的生物复合材料（CH@ZPh/HPANRs），改善了传统奥沙利铂的递送结构。 OXPN）治疗结直肠癌细胞期间的化疗。基于负载、释放和细胞毒性，对 CH@ZPh/HPANR 与 ZPh/HPANR 作为 OXPN 载体的资格进行了比较。 CH@ZPh/HPANRs 复合材料的 OXPN 负载能力 (321.75mg/g) 明显高于 ZPh/HPANRs (127.2mg/g)。 OXPN 封装到 CH@ZPh/HPANR 中的过程显示了 Langmuir 模型的等温线行为 (R2=0.99) 和伪一级动力学的动力学假设 (R2>0.89)。空间研究反映了与纯 ZPh/HPANR (Nm=18.7mg/g) 相比，壳聚糖杂交步骤 (Nm=34.6mg/g) 后游离位点数量的大幅增加。此外，每个位点的容量也得到增强，可以在垂直方向上装载 10 个 OXPN 分子（n=9.3）。 CH@ZPh/HPANRs 中的 OXPN 负载能量 (<40 KJ/mol) 反映了涉及范德华力和氢键的物理负载反应。 CH@ZPh/HPANRs 的 OXPN 释放曲线在 pH7.4 下约 140 小时和在 pH5.5 下约 80 小时表现出缓慢且受控的特性。释放动力学和扩散指数（>0.45）表示非菲克传输和复杂的侵蚀/扩散释放机制。游离的 CH@ZPh/HPANRs 颗粒对 HCT-116 癌细胞表现出相当大的细胞毒性作用（9.53% 细胞活力），其 OXPN 负载产品显示出很强的细胞毒性作用（1.83% 细胞活力）。版权所有 © 2023 Elsevier B.V.版权所有。

An advanced form of zinc phosphate/hydroxyapatite nanorods with a core-shell structure (ZPh/HPANRs) was made and then hybridized with chitosan polymeric chains to make a safe biocomposite (CH@ZPh/HPANRs) that improves the delivery structure of traditional oxaliplatin (OXPN) chemotherapy during the treatment of colorectal cancer cells. The qualifications of CH@ZPh/HPANRs in comparison with ZPh/HPANRs as a carrier for OXPN were followed based on loading, release, and cytotoxicity. CH@ZPh/HPANRs composite exhibits a notably higher OXPN loading capacity (321.75 mg/g) than ZPh/HPANRs (127.2 mg/g). The OXPN encapsulation processes into CH@ZPh/HPANRs display the isotherm behavior of the Langmuir model (R2 = 0.99) and the kinetic assumptions of pseudo-first-order kinetics (R2 > 0.89). The steric studies reflect a strong increment in the quantities of the free sites after the chitosan hybridization steps (Nm = 34.6 mg/g) as compared to pure ZPh/HPANRs (Nm = 18.7 mg/g). Also, the capacity of each site was enhanced to be loaded by 10 OXPN molecules (n = 9.3) in a vertical orientation. The OXPN loading energy into CH@ZPh/HPANRs (<40 KJ/mol) reflects physical loading reactions involving van der Waals forces and hydrogen bonding. The OXPN release profiles of CH@ZPh/HPANRs exhibit slow and controlled properties for about 140 h at pH 7.4 and 80 h at pH 5.5. The release kinetics and diffusion exponent (>0.45) signify non-Fickian transport and a complex erosion/diffusion release mechanism. The free CH@ZPh/HPANRs particles display a considerable cytotoxic effect on the HCT-116 cancer cells (9.53 % cell viability), and their OXPN-loaded product shows a strong cytotoxic effect (1.83 % cell viability).Copyright © 2023 Elsevier B.V. All rights reserved.