癌症和心血管疾病都会相互产生不利影响。我们当前研究的目的是调查在一个独特的心脏肿瘤中心接受乳腺癌和淋巴瘤治疗的患者的心功能障碍，包括其患病率和相关因素。 方法：一项单中心回顾性研究纳入了 180 名患有乳腺癌和淋巴瘤的患者，这些患者均患有乳腺癌和淋巴瘤。并于 2019 年 1 月至 2022 年 2 月在我们的肿瘤中心接受治疗 结果：：在 180 名连续患者中，155 名患者 (86%) 被诊断为乳腺癌，25 名患者 (14%) 被诊断为淋巴瘤。淋巴瘤患者年龄较大、肥胖程度较低，且糖尿病 (DM) 患病率较高（P 分别为 0.026、0.05 和 0.04）。他们还表现出治疗后左心室（LV）扩张更多，整体纵向应变（GLS）值更低；然而，与癌症乳腺癌患者相比，他们并没有出现更多的左室功能障碍。此外，淋巴瘤患者的院内结局较差（感染、心包积液和死亡率分别 P= 0.04、0.001 和 0.015）。在我们的 41 名患者 (23%) 中观察到癌症治疗相关的心功能障碍 (CTRCD)。本研究中 CTRCD 的独立预测因素是 DM、低体重指数 (BMI) 和曲妥珠单抗的使用 结论：：一些接受乳腺癌和淋巴瘤治疗的患者出现左室功能障碍。与乳腺癌患者相比，淋巴瘤患者表现出更多的亚临床左心室功能障碍和较差的院内结局。糖尿病、低体重指数 (BMI) 和曲妥珠单抗的使用是我们患者心功能障碍的独立预测因素。版权所有 © 2023。由 Elsevier Inc. 出版。

Cancer and cardiovascular diseases both have adverse effects on each other. We aim in the current study to investigate cardiac dysfunction including its prevalence, and associated factors in patients treated for breast cancer and lymphoma in a unique cardiac oncology center METHODS: : A single-center retrospective study included 180 patients with cancer breast and lymphoma who presented and were treated at our oncology center from January 2019 to February 2022 RESULT: : Out of 180 consecutive patients, 155 patients (86%) were diagnosed with cancer breast and 25 patients (14%) were diagnosed with lymphoma. Patients with lymphoma were older age, less obese, and showed more prevalence of diabetes mellitus (DM) (P= 0.026, 0.05, and 0.04 respectively). They also showed more post-therapy left ventricular (LV) dilatation and lower values of global longitudinal strain (GLS); however, they did not develop more LV dysfunction compared to cancer breast patients. Moreover, lymphoma patients showed poor in-hospital outcomes (P= 0.04, 0.001, and 0.015 for infection, pericardial effusion, and mortality respectively). Cancer therapy-related cardiac dysfunction (CTRCD) was observed in 41 patients (23%) of our population. The independent predictors of CTRCD in the current study were DM, low body mass index (BMI), and the use of trastuzumab CONCLUSIONS: : Some patients treated for breast cancer and lymphoma develop LV dysfunction. Lymphoma patients showed more subclinical LV dysfunction and poor in-hospital outcomes compared to patients with cancer breast. DM, low body mass index (BMI), and the use of trastuzumab were the independent predictors of cardiac dysfunction among our patients.Copyright © 2023. Published by Elsevier Inc.