癌症是全世界死亡的主要原因。然而，传统的癌症治疗仍然存在一些局限性，例如全身副作用、疗效差以及由于肿瘤部位的可达性有限而导致患者依从性差。为了解决这些问题，局部给药系统已成为一种有前景的方法。在这项研究中，我们开发了一种基于离子电渗疗法的透皮给药系统（TDDS），由智能手机应用程序控制，用于癌症治疗。离子电渗疗法是一种基于低强度电流的 TDDS，可增强药物在皮肤上的渗透，从而提供局部药物输送的潜力并最大限度地减少全身副作用。我们系统的基本机制是使用有限元分析进行建模的，其性能通过使用基于塑料的微流控芯片的流通式皮肤渗透测试得到了证实。体外细胞实验和皮肤沉积测试的结果成功证明我们的智能手机控制的离子电渗疗法系统显着增强了癌症治疗的药物渗透性。因此，这种基于手持式智能手机的离子电渗疗法 TDDS 可以成为自我管理抗癌药物输送应用的强大工具。版权所有 © 2023 Elsevier B.V. 保留所有权利。

Cancer is a leading cause of the death worldwide. However, the conventional cancer therapy still suffers from several limitations, such as systemic side effects, poor efficacy, and patient compliance due to limited accessibility to the tumor site. To address these issues, the localized drug delivery system has emerged as a promising approach. In this study, we developed an iontophoresis-based transdermal drug delivery system (TDDS) controlled by a smartphone application for cancer treatment. Iontophoresis, a low-intensity electric current-based TDDS, enhances drug permeation across the skin to provide potential for localized drug delivery and minimize systemic side effects. The fundamental mechanism of our system was modeled using finite element analysis and its performance was corroborated through the flow-through skin permeation tests using a plastic-based microfluidic chip. The results of in vitro cell experiments and skin deposition tests successfully demonstrated that our smartphone-controlled iontophoresis system significantly enhanced the drug permeation for cancer treatment. Therefore, this hand-held smartphone-based iontophoresis TDDS could be a powerful tool for self-administrated anticancer drug delivery applications.Copyright © 2023 Elsevier B.V. All rights reserved.