白藜芦醇是一种天然有机多羟基酚化合物，由于其潜在的健康益处（包括抗氧化、抗癌和抗炎特性），在过去几年中受到了广泛关注。它可以直接从植物、蔬菜及相关产品和废物资源中提取，也可以通过化学/酶法/微生物合成。然而，某些工艺策略具有一些局限性，例如成本高、产量降低或能源需求高，从而意味着显着的环境负荷。在此背景下，寻找更可持续和循环的工艺方案是将白藜芦醇融入食品、化妆品和制药行业市场价值链的关键。白藜芦醇的提取传统上基于溶剂提取等传统方法，但先进的绿色提取技术提供了更高效、更环保的替代方案。本综述从生产能力、产量、纯度和可持续性方面分析了传统和绿色替代提取技术，以及通过微生物发酵进行的生物生产。它还提出了基于白藜芦醇生物生产的替代生物精炼模型，使用副产品和废物流作为资源，特别考虑酒渣、花生壳和木树皮作为输入资源，并遵循循环方法。这项批判性审查提供了一些关于白藜芦醇为促进相关市场价值链的可持续发展和循环性的机会的见解，从而为生物精炼模型的决策提供了一些标准，其中白藜芦醇是目标高附加值产品之一。它还确定了促进白藜芦醇纳入价值链的未来挑战，其中最突出的是绿色技术的规模化及其经证明的经济可行性。版权所有 © 2023 作者。由 Elsevier B.V. 出版。保留所有权利。

Resveratrol, a natural organic polyhydroxyphenolic compound, has gained significant attention in the last years given its potential health benefits, including antioxidant, anti-cancer, and anti-inflammatory properties. It can be directly extracted from plants, vegetables, and related products and waste resources, but also chemically/enzymatically/microbially synthesized. However, certain process strategies have some limitations, such as high costs, reduced yield or high energy demand, thus implying significant environmental loads. In this context, the search for more sustainable and circular process schemes is key to the integration of resveratrol into the market value chain of the food, cosmetic and pharmaceutical sectors. The extraction of resveratrol has traditionally been based on conventional methods such as solvent extraction, but advanced green extraction techniques offer more efficient and environmentally friendly alternatives. This review analyses both conventional and green alternative extraction technologies, as well as its bioproduction through microbial fermentation, in terms of production capacity, yield, purity and sustainability. It also presents alternative biorefinery models based on resveratrol bioproduction using by-products and waste streams as resources, specifically considering wine residues, peanut shells and wood bark as input resources, and also following a circular approach. This critical review provides some insight into the opportunities that resveratrol offers for promoting sustainable development and circularity in the related market value chains, and thus provides some criteria for decision making for biorefinery models in which resveratrol is one of the targeted high value-added products. It also identifies the future challenges to promote the inclusion of resveratrol in value chains, with the scale-up of green technologies and its demonstrated economic feasibility being the most prominent.Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.