疲劳是最常见但人们最了解的放疗相关毒性之一。这项前瞻性研究旨在调查心肺健康（全身心肺功能的综合衡量指标）是否与接受放射治疗的早期乳腺癌女性患者报告的疲劳有关。 Tis-T2N0M0 期乳腺癌且有 ECOG 表现的患者接受乳房放射治疗的状态为 0-1 的患者在电动跑步机上进行症状限制心肺运动测试 (CPET)，以评估心肺健康 (VO2peak)。通过 FACIT 疲劳量表评估疲劳。两项评估均在放疗完成期间或放疗完成后立即进行。所有患者均采用对向切线技术进行治疗，剂量为 4240 cGy，分 16 次进行，有或没有肿瘤切除床加强治疗。接受细胞毒性化疗的患者被排除在外。 Pearson 相关系数和单变量线性回归用于评估 VO2peak、疲劳和患者特征之间的关联。28 名患者（中位年龄 52 岁，范围 31-71）完成了 CPET 和 FACIT 评估。中位 VO2peak 为 25.1 mL O2.kg-1.min-1（范围 16.7-41.7）。大多数受试者 (78.6%) 的摄氧量峰值低于其年龄预测的摄氧量峰值。年龄和 BMI 均与 VO2peak 水平显着相关。疲劳评分中位数为 41.5（范围 10-52），数值越低表明疲劳程度越高。 VO2peak 与 FACIT 评分无关 (p=0.20)。总体而言，VO2peak 并不是放疗相关疲劳的显着预测因子。根据 VO2peak 测定，大多数乳腺癌患者的心肺健康有明显损害。需要进行更大规模的前瞻性研究来进一步研究这一新发现，并评估旨在改善心肺健康及其潜在预防疲劳能力的干预措施的效果。版权所有 © 2023。由 Elsevier Inc. 出版。

Fatigue is among the most common but one of the most poorly understood radiotherapy-associated toxicities. This prospective study sought to investigate whether cardiorespiratory fitness, an integrative measure of whole-body cardiopulmonary function, is associated with patient-reported fatigue among women with early-stage breast cancer undergoing radiotherapy.Patients with stage Tis-T2N0M0 breast cancer and an ECOG performance status of 0-1 who were undergoing breast radiotherapy performed a symptom-limited cardiopulmonary exercise test (CPET) on a motorized treadmill to assess cardiorespiratory fitness (VO2peak). Fatigue was assessed by the FACIT Fatigue Scale. Both assessments were performed during or immediately after radiotherapy completion. All patients were treated with an opposed tangent technique to a dose of 4240 cGy in 16 fractions with or without a lumpectomy bed boost. Patients receiving cytotoxic chemotherapy were excluded. Pearson's correlation coefficients and univariate linear regression were used to assess associations between VO2peak, fatigue, and patient characteristics.Twenty-eight patients (median age 52 years, range 31-71) completed both CPET and FACIT assessments. Median VO2peak was 25.1 mL O2.kg-1.min-1 (range 16.7-41.7). The majority of subjects (78.6%) displayed a VO2peak less than their age-predicted VO2peak. Both age and BMI were significantly associated with VO2peak levels. Median fatigue score was 41.5 (range 10-52), with lower values indicating more fatigue. VO2peak was not associated with FACIT score (p=0.20).Overall, VO2peak was not a significant predictor of radiotherapy-related fatigue. Most breast cancer patients had marked impairments in cardiorespiratory fitness as determined by VO2peak. Larger prospective studies are needed to further investigate this novel finding, and to evaluate the effects of interventions aimed at improving cardiorespiratory fitness and their ability to potentially prevent fatigue.Copyright © 2023. Published by Elsevier Inc.