种族和社会经济因素影响乳腺癌的结果。我们的目的是评估种族和社区社会经济地位 (SES) 对转移性乳腺癌 (MBC) 患者总体生存率和治疗模式的影响。这是一项回顾性队列研究，纳入 2000 年至 2017 年在 UPMC Magee 女性乳腺癌诊所诊断出远处乳腺癌转移的患者 (N = 1246)。比较了种族（黑人和白人）和 SES 群体（使用面积剥夺指数定义）之间的总体生存率和治疗模式。在研究人群中，低SES与黑人种族相关，但与肿瘤特征无关（P < 0.001）。低 SES（中位 [四分位距，IQR] 生存期 2.3[2.2-2.5] 年 vs 高 SES 2.7[2.5-3.1] 年，P = 0.01）和黑人种族（中位 [IQR] 生存期 1.8[1.3-2.3] 年，与白人相比，2.5[2.3-2.7]岁（P = 0.008）分别与 MBC 患者较差的总生存率相关。在以 SES、种族、年龄、亚型、转移数量、内脏转移和诊断年份作为协变量的 Cox 比例风险模型中，SES 较低（风险比 1.19[1.04-1.35]，P = 0.01），但黑人种除外（风险比 1.19[0.96-1.49]，P = 0.12），独立预测 MBC 的总生存期。此外，来自社会经济地位低的社区和黑人的患者比社会经济地位高的社区和白人接受的化疗更少。总之，较低的社区 SES 与 MBC 患者的预后较差相关。黑人 MBC 患者的不良预后至少部分是由社会经济因素造成的。未来的研究应该在 MBC 中描述社区社会经济地位、种族及其对肿瘤生物学的影响之间的相互作用。© 2023。作者。

Race and socioeconomic factors affect outcomes in breast cancer. We aimed to assess the effect of race and neighborhood socioeconomic status (SES) on overall survival and treatment patterns in patients with metastatic breast cancer (MBC). This is a retrospective cohort study involving patients (N = 1246) with distant breast cancer metastases diagnosed at UPMC Magee Women's Breast Cancer Clinic from 2000-2017. Overall survival and treatment patterns were compared between races (Blacks and whites) and SES groups (defined using Area Deprivation Index). Low SES, but not tumor characteristics, was associated with Black race (P < 0.001) in the study population. Low SES (Median [Interquartile Range, IQR] survival 2.3[2.2-2.5] years vs high SES 2.7[2.5-3.1] years, P = 0.01) and Black race (Median [IQR] survival 1.8[1.3-2.3] years, vs white 2.5[2.3-2.7] years P = 0.008) separately were associated with worse overall survival in patients with MBC. In the Cox Proportional Hazard model with SES, race, age, subtype, number of metastases, visceral metastasis, and year of diagnosis as covariates, low SES (Hazard ratio 1.19[1.04-1.35], P = 0.01), but not Black race (Hazard ratio 1.19[0.96-1.49], P = 0.12), independently predicted overall survival in MBC. Moreover, patients from low SES neighborhoods and Black race received fewer lines of chemotherapy than high SES and whites. In conclusion, low neighborhood SES is associated with worse outcomes in patients with MBC. Poor outcomes in Black patients with MBC, at least in part is driven by socioeconomic factors. Future studies should delineate the interplay between neighborhood SES, race, and their effects on tumor biology in MBC.© 2023. The Author(s).