肿瘤微环境（TME）是由各种细胞和细胞外基质组成的内部环境。肿瘤干细胞源性外泌体（CSC-Exos）作为参与肿瘤多种过程的重要信使，是肿瘤微环境与肿瘤细胞双向通讯的重要载体，在肿瘤微环境中发挥着重要作用。然而，该领域系统研究的文献计量分析还很少。因此，我们旨在通过文献计量可视化该领域的研究热点和趋势，以了解基础和临床研究的未来演变，并提供有洞察力的信息和新鲜的观点。 。该库建立后，利用Scopus数据库检索外泌体和肿瘤微环境相关的研究文献。使用CiteSpace（5.8.R3版）和VOSviewer（1.6.16版）进行可视化和分析。本研究共纳入2077篇文章和综述，其中关于外泌体和肿瘤微环境的文章数量逐年显着增加。近期趋势表明，外泌体作为“肿瘤诊断”的潜在价值以及“外泌体作为治疗剂和药物递送载体的应用前景”未来将受到更多关注。我们揭示了肿瘤干细胞来源的现状和热点通过文献计量学研究全球外泌体和肿瘤微环境。 CSC-Exos在TME中的调控作用的前景、诊断的潜在价值以及药物递送载体的应用都将仍然是肿瘤治疗领域的前沿研究领域。同时，本研究为相关研究人员提供了功能性文献分析。© 2023。作者。

The tumor microenvironment (TME) is an internal environment composed of various cells and an extracellular matrix. Cancer stem cell-derived exosomes (CSC-Exos), as essential messengers involved in various tumor processes, are important carriers for bidirectional communication between the tumor microenvironment and tumor cells and play an important role in the tumor microenvironment. Nevertheless, few bibliometric analyses have been systematically studied in this field.Therefore, we aimed to visualize the research hotspots and trends in this field through bibliometrics to comprehend the future evolution of fundamental and clinical research, as well as to offer insightful information and fresh viewpoints. The Scopus database was used to search the research literature related to exosomes and tumor microenvironments after the establishment of this repository. CiteSpace (version 5.8.R3) and VOSviewer (version 1.6.16) were used for visualization and analysis.In this study, a total of 2077 articles and reviews were included, with the number of articles on exosomes and tumor microenvironments significantly increasing yearly. Recent trends showed that the potential value of exosomes as "tumor diagnostics" and "the application prospect of exosomes as therapeutic agents and drug delivery carriers" will receive more attention in the future.We revealed the current status and hotspots of tumor stem cell-derived exosomes and tumor microenvironments globally through bibliometrics. The prospect of the regulatory role of CSC-Exos in TME, the potential value of diagnosis, and the application of drug delivery vectors will all remain cutting-edge research areas in the field of tumor therapy. Meanwhile, this study provided a functional literature analysis for related researchers.© 2023. The Author(s).