磷酸肌醇 3 激酶 (PI3K)/AKT 信号通路在癌症的发病机制中发挥着至关重要的作用。该通路的失调与各种癌症的发生和发生有关。最近，表观遗传修饰，特别是 N6-甲基腺苷 (m6A)，已被认为是 mRNA 相关生物过程和翻译的重要贡献者。 m6A 修饰酶的异常表达与肿瘤发生、肿瘤进展和耐药性相关。在这里，我们回顾了 m6A 修饰在调节癌症 PI3K/AKT 通路中的作用及其对开发癌症治疗新策略的影响。© 2023。作者。

The phosphoinositide 3-kinase (PI3K)/AKT signaling pathway plays a crucial role in the pathogenesis of cancer. The dysregulation of this pathway has been linked to the development and initiation of various types of cancer. Recently, epigenetic modifications, particularly N6-methyladenosine (m6A), have been recognized as essential contributors to mRNA-related biological processes and translation. The abnormal expression of m6A modification enzymes has been associated with oncogenesis, tumor progression, and drug resistance. Here, we review the role of m6A modification in regulating the PI3K/AKT pathway in cancer and its implications in the development of novel strategies for cancer treatment.© 2023. The Author(s).