浸润性宫颈癌 (ICC) 是一种与 HIV 相关的癌症，是可以预防的，并且可以通过筛查发现癌前阶段，包括早期 ICC 阶段，从而提供治疗和治愈的机会。女性艾滋病毒感染者的高发病率以及晚期就诊通常处于 ICC 晚期且治疗设施有限，常常导致早期死亡。我们试图比较尼日利亚 ICC 患者 HIV 状态的流行病学特征和生存差异。我们于 2018 年 3 月至2022 年 9 月。我们招募了经组织学证实具有已知 HIV 状况的 ICC 的女性，并进行了 Figo 分期，作为美国国立卫生研究院/国家癌症研究所资助的题为“尼日利亚 HIV 相关癌症的表观基因组生物标志物”项目的一部分。主要结局是全因死亡率，并评估 ICC 诊断后的总生存期 (OS) 和死亡时间。使用 Kaplan-Meier 方法估计 OS 分布，并使用对数秩检验进行组间比较。 共有 239 名确诊 ICC 的女性被纳入本次分析，其中 192 名 (80.3%) 为 HIV 阴性（ HIV-/ICC  ），47 人（19.7%）为 HIV 阳性（HIV  /ICC  ）。 HIV /ICC 患者较年轻，中位年龄为46岁（IQR：40-51），而HIV-/ICC 患者中位年龄为57岁（IQR：45-66）（P < 0.001）。鳞状细胞癌是 80.4% ICC 诊断中最常见的组织病理学变异，两组中 68.1% 的肿瘤分级为中分化。 HIV /ICC 诊断处于FIGO晚期的比例为64.9%，而HIV-/ICC 诊断为47.9%。与 HIV  /ICC  参与者相比，HIV-/ICC 女性的 OS 更好 (p = 0.018)，12 个月 OS 分别为 84.1% (95%CI 75-90%) 和 67.6% (95%CI 42-84%) . 感染艾滋病毒的女性在相对年轻的时候就被诊断出 ICC，与未感染艾滋病毒的女性相比，其总体生存概率显着较低。 HIV 感染女性晚期的表现和诊断趋势可以部分解释总体生存率的差异。© 2023。作者。

Invasive cervical cancer (ICC) is an HIV-associated cancer that is preventable and precancerous stages including early ICC stages could be detected through screening offering opportunities for treatment and cure. The high incidence in women living with HIV and late presentation often at advanced stages of ICC with limited treatment facilities often result in early mortality. We sought to compare the epidemiologic characteristics and survival differences in HIV status of ICC patients in Nigeria.We conducted a cohort study at two federal academic hospital-based research sites in Jos University Teaching Hospital, and Lagos University Teaching Hospital Nigeria, between March 2018 and September 2022. We enrolled women with histologically confirmed ICC with known HIV status, and FIGO staging as part of the United States of America's National Institutes of Health/National Cancer Institute funded project titled 'Epigenomic Biomarkers of HIV-Associated Cancers in Nigeria'. The primary outcome was all-cause mortality with assessment of overall survival (OS) and time to death after ICC diagnosis. OS distribution was estimated using the method of Kaplan-Meier and compared between groups using the log-rank test.A total of 239 women with confirmed ICC were enrolled and included in this analysis, of whom 192 (80.3%) were HIV-negative (HIV-/ICC +), and 47 (19.7%) were HIV-positive (HIV +/ICC +). The HIV +/ICC + patients were younger with median age 46 (IQR: 40-51) years compared to 57 (IQR: 45-66) among HIV-/ICC + (P < 0.001). Squamous cell carcinoma was the commonest histopathologic variant in 80.4% of ICC diagnosis, moderately differentiated tumor grade in 68.1% in both groups. HIV +/ICC + diagnosis was at FIGO advanced stages in 64.9% compared to 47.9% in HIV-/ICC +. The HIV-/ICC + women had better OS compared to HIV +/ICC + participants (p = 0.018), with 12-month OS 84.1% (95%CI 75-90%) and 67.6% (95%CI 42-84%) respectively.ICC is diagnosed at a relatively young age in women living with HIV, with a significantly lower overall survival probability compared to women without HIV. The trend of presentation and diagnosis at advanced stages in women living with HIV could partly explain the differences in overall survival.© 2023. The Author(s).