乳酸脱氢酶（LDH）是参与能量代谢的关键酶，存在于全身的各种细胞中。其多种生理功能包括糖酵解，其异常活性与多种疾病相关。靶向 LDH 已成为药物发现的重要方法，导致在多酚、生物碱和萜类化合物等天然化合物中鉴定出 LDH 抑制剂。这些化合物显示出针对 LDH 相关疾病的治疗潜力，包括抗癌作用。然而，必须解决生物利用度有限、溶解度差和潜在毒性等挑战。将天然化合物与 LDH 抑制剂相结合，在临床前研究中取得了有希望的结果。本综述强调了天然化合物作为 LDH 抑制剂治疗癌症、心血管和神经退行性疾病的前景。版权所有 © 2023 Han、Lee、Park、Ha 和 Chung。

Lactate dehydrogenase (LDH) is a crucial enzyme involved in energy metabolism and present in various cells throughout the body. Its diverse physiological functions encompass glycolysis, and its abnormal activity is associated with numerous diseases. Targeting LDH has emerged as a vital approach in drug discovery, leading to the identification of LDH inhibitors among natural compounds, such as polyphenols, alkaloids, and terpenoids. These compounds demonstrate therapeutic potential against LDH-related diseases, including anti-cancer effects. However, challenges concerning limited bioavailability, poor solubility, and potential toxicity must be addressed. Combining natural compounds with LDH inhibitors has led to promising outcomes in preclinical studies. This review highlights the promise of natural compounds as LDH inhibitors for treating cancer, cardiovascular, and neurodegenerative diseases.Copyright © 2023 Han, Lee, Park, Ha and Chung.