心脏代谢疾病和癌症是世界范围内最常见的疾病，也是医疗保健系统严重关注的问题。这些看似遥远的疾病具有共同的分子和细胞决定因素，可以代表预防和治疗方法的目标。骨髓在这方面发挥着重要作用，因为它是参与心血管再生的细胞的主要来源，也是液体和实体肿瘤转移的主要部位之一，两者都以跨骨髓脉管系统的细胞运输为特征。骨髓脉管系统已在动物模型中得到广泛研究，然而，显然需要人类特异性的体外模型，类似于内皮细胞排列的骨脉管系统，以研究控制细胞运输的分子机制。在这篇综述中，我们总结了为心血管和癌症研究开发的骨髓脉管系统体外模型的当前知识。© 2023 Campanile、Bettinelli、Cerutti 和 Spinetti。

Cardiometabolic diseases and cancer are among the most common diseases worldwide and are a serious concern to the healthcare system. These conditions, apparently distant, share common molecular and cellular determinants, that can represent targets for preventive and therapeutic approaches. The bone marrow plays an important role in this context as it is the main source of cells involved in cardiovascular regeneration, and one of the main sites of liquid and solid tumor metastasis, both characterized by the cellular trafficking across the bone marrow vasculature. The bone marrow vasculature has been widely studied in animal models, however, it is clear the need for human-specific in vitro models, that resemble the bone vasculature lined by endothelial cells to study the molecular mechanisms governing cell trafficking. In this review, we summarized the current knowledge on in vitro models of bone marrow vasculature developed for cardiovascular and cancer research.© 2023 Campanile, Bettinelli, Cerutti and Spinetti.