将诊断和治疗功能集成到具有肿瘤微环境（TME）智能响应功能的生物安全纳米平台中是一种有前景的癌症治疗策略。通过简单的共沉淀方法成功制备了锰掺杂纳米羟基磷灰石（nHAPMn）纳米粒子磁共振成像（MRI）引导的光热疗法。该研究首次报道了通过在制备过程中调节nHAPMn的pH值，利用Mn使可生物降解的羟基磷灰石同时适用于MRI和有效的光热疗法（PTT）。结合近红外（NIR）激光照射，实现了26%的光热转换效率和体外有效光热致死作用。此外，nHAPMn的降解导致Mn离子的释放并放大了酸性TME中的MRI信号，这证实了nHAPMn在实体瘤中具有良好的pH响应MRI能力。在动物实验中，nHAPMn5 NIR组的肿瘤在治疗14天后完全消退，并且在实验过程中没有明显复发。因此，nHAPMn作为纳米治疗剂很有前景，可以有效地用于癌症的临床诊断和治疗。© 2023李等人。

The integration of diagnostic and therapeutic functions into a biosafe nanoplatform with intelligent response functions at the tumor microenvironment (TME) is a promising strategy for cancer therapy.Mn-doped nano-hydroxyapatite (nHAPMn) nanoparticles were successfully prepared via a simple coprecipitation method for magnetic resonance imaging (MRI)-guided photothermal therapy. This study is the first to report on the use of Mn to render biodegradable hydroxyapatite suitable for MRI and effective photothermal therapy (PTT) simultaneously by regulating the pH of nHAPMn during the preparation process.Combined with near-infrared (NIR) laser irradiation, a photothermal conversion efficiency of 26% and effective photothermal lethality in vitro were achieved. Moreover, the degradation of nHAPMn led to the release of Mn ions and amplified the MRI signals in an acidic TME, which confirmed that nHAPMn had a good pH-responsive MRI capacity in solid tumors. In animal experiments, tumors in the nHAPMn5+NIR group completely abated after 14 days of treatment, with no significant recurrence during the experiment.Therefore, nHAPMn is promising as a nanotheranostic agent and can be effective in clinical diagnosis and therapy for treating cancer.© 2023 Li et al.