肾切除术中的非肿瘤性肾实质在常规检查中经常被忽视。我们的目的是评估整体肾小球硬化 (GS)、间质纤维化 (IF) 或动脉硬化 (AS) 与估计肾小球滤过率 (eGFR)、试纸蛋白尿和其他临床因素之间的关联。我们对 781 例患者进行了横断面分析肾切除术患者。我们使用有和没有交互因素的回归模型。测试的暴露是 GS、IF 或 AS，结果指标是 GFR 和试纸蛋白尿。在多变量分析中，GS、IF 或 AS 程度的增加与较低的 eGFR 和蛋白尿显着相关（各自的 p < 0.05）。肥胖和高血压 (HTN) 改变了 eGFR 与 GS 程度之间的关联，而蛋白尿和心血管疾病 (CVD) 改变了 eGFR 与 AS 程度之间的关联（交互作用 p <0.05）。与 GS <10% 相比，GS >50% 与肥胖患者 (-45 mL/min/1.73 m2) 的 eGFR 低于无肥胖患者 (-19 mL/min/1.73 m2) 相关，GS >50% 与肥胖患者 eGFR 较低相关。患有 (-31 mL/min/1.73 m2) 高血压的患者的 eGFR 低于未患有 (-16 mL/min/1.73 m2) 高血压的患者。与 AS <26% 相比，AS >50% 与蛋白尿患者 (-11 mL/min/1.73 m2) 的 eGFR 低于无蛋白尿患者 (-6 mL/min/1.73 m2) 相关，而 AS >50% 则与蛋白尿患者的 eGFR 较低相关。患有 (-23 mL/min/1.73 m2) CVD 的患者的 eGFR 低于无 (-7 mL/min/1.73 m2) CVD 的患者。GS、IF 和 AS 的程度均与蛋白尿和较低的 eGFR 独立相关。肥胖、高血压、蛋白尿和 CVD 改变了 eGFR 与肾硬化特定组织病理学特征之间的关系。© 2023 作者。由巴塞尔 S. Karger AG 出版。

The non-neoplastic kidney parenchyma from nephrectomies is often overlooked in routine examinations. We aimed to evaluate the associations between global glomerulosclerosis (GS), interstitial fibrosis (IF), or arteriosclerosis (AS) and estimated glomerular filtration rate (eGFR), dipstick proteinuria, and other clinical factors.We performed a cross-sectional analysis of 781 patients with nephrectomy. We used regression models with and without interaction factors. The tested exposures were GS, IF, or AS, and the outcome measures were GFR and dipstick proteinuria.In multivariable analyses, increasing degrees of GS, IF, or AS were significantly associated with lower eGFR and proteinuria (p < 0.05 for each). Obesity and hypertension (HTN) modified the association between eGFR and degrees of GS, whereas proteinuria and cardiovascular disease (CVD) modified the association between eGFR and degrees of AS (p for interaction <0.05). Compared with GS <10%, GS >50% was associated with lower eGFR in patients with (-45 mL/min/1.73 m2) than without (-19 mL/min/1.73 m2) obesity, and GS >50% was associated with lower eGFR in patients with (-31 mL/min/1.73 m2) than without (-16 mL/min/1.73 m2) HTN. Compared with AS <26%, AS >50% was associated with lower eGFR in patients with (-11 mL/min/1.73 m2) than without (-6 mL/min/1.73 m2) proteinuria, and AS >50% was associated with lower eGFR in patients with (-23 mL/min/1.73 m2) than without (-7 mL/min/1.73 m2) CVD.Greater degrees of each GS, IF, and AS are independently associated with proteinuria and lower eGFR. Obesity, HTN, proteinuria, and CVD modify the relationship between eGFR and specific histopathological features of nephrosclerosis.© 2023 The Author(s). Published by S. Karger AG, Basel.