初次手术将肿瘤和同侧甲状腺叶完全切除是治疗甲状旁腺癌（PC）的“金标准”。然而，接受部分和全部手术切除的 PC 患者的总生存期 (OS) 差异仍有待确定。接受部分和全部手术切除的 PC 患者的数据提取自监测、流行病学和最终结果 (SEER) ）数据库（2000-2018）。 X-tile 软件 (https://medicine.yale.edu/lab/rimm/research/software/) 用于定义连续变量的最佳截止值。采用处理加权逆概率（IPTW）方法来减少选择偏差。采用 IPTW 调整的 Kaplan-Meier 曲线和 Cox 比例风险模型比较部分切除组和全部手术切除组 PC 患者的 OS。 本研究共纳入 334 例 PC 患者（部分切除组 183 例，部分切除组 151 例）。和全手术切除组，分别）。诊断时年龄的最佳临界值分别为 53 岁和 73 岁，而肿瘤大小的最佳临界值为 34 毫米。在IPTW前的Kaplan-Meier分析和单变量Cox比例风险回归分析中，部分手术切除组和全部手术切除组之间的OS差异均无统计学意义（p>0.05）。这些发现在 IPTW 调整的 Kaplan-Meier 分析和多变量 Cox 比例风险回归分析中得到证实 (p>0.05)。亚组分析显示，仅在肿瘤大小未知的亚组中，完全手术切除对 OS 有益。接受部分和完全手术切除的患者预后无显着差异。这一发现可能为PC的治疗提供有用的参考。Copyright © 2023 Jin, Cho, Yang, Xia and Zhou.

Complete resection of the tumor and the ipsilateral thyroid lobe at the primary surgery is the "gold standard" for the treatment of parathyroid carcinoma (PC). However, differences in the overall survival (OS) of patients with PC who underwent partial and total surgical resection remain to be determined.Data on patients with PC who underwent partial and total surgical resection were extracted from the Surveillance, Epidemiology and End Results (SEER) database (2000-2018). The X-tile software (https://medicine.yale.edu/lab/rimm/research/software/) was used to define the optimal cut-off values for continuous variables. The inverse probability of treatment weighting (IPTW) method was used to reduce the selection bias. IPTW-adjusted Kaplan-Meier curves and Cox proportional hazards models were used to compare the OS of patients with PC in the partial and total surgical resection groups.A total of 334 patients with PC were included in this study (183 and 151 in the partial and total surgical resection groups, respectively). The optimal cut-off values for age at diagnosis were 53 and 73 years, respectively, while that for tumor size was 34 mm. In both the Kaplan-Meier analysis and univariable Cox proportional hazards regression analysis before IPTW, the difference in OS between the partial and total surgical resection groups was not statistically significant (p>0.05). These findings were confirmed in the IPTW-adjusted Kaplan-Meier analysis and multivariate Cox proportional hazards regression analysis (p>0.05). Subgroup analysis revealed that total surgical resection was beneficial for OS only in the subgroup with unknown tumor size.There was no significant difference in the prognosis of patients who underwent partial and total surgical resection. This finding may provide a useful reference for the treatment of PC.Copyright © 2023 Jin, Cho, Yang, Xia and Zhou.