血细胞比容值异常，包括贫血和红细胞增多症，在接受开颅手术的患者中很常见，但术前贫血或红细胞增多症独立增加死亡风险的程度尚不清楚。这项回顾性队列研究旨在探讨接受开颅脑肿瘤切除术的患者术前贫血和红细胞增多症与术后死亡率之间的关系。我们回顾性分析了2011年1月期间在华西医院接受颅脑手术的12,170例诊断为脑肿瘤的患者的数据。 2021年3月。术前红细胞压积值定义为术前7天内最后一次红细胞压积值，根据贫血或红细胞增多症的严重程度对患者进行分组。我们使用逻辑回归分析评估了术后 30 天死亡率的主要结果，并根据潜在的混杂因素进行了调整。多变量逻辑回归分析表明，随着贫血和红细胞增多症严重程度的增加，30 天死亡风险也会增加。轻度、中度和重度贫血的比值比分别为 1.12 (95% CI: 0.79-1.60)、1.66 (95% CI: 1.06-2.58) 和 2.24 (95% CI: 0.99-5.06)。轻度、中度和重度红细胞增多症的比值比分别为 1.40 (95% CI: 0.95-2.07)、2.81 (95% CI: 1.32-5.99) 和 14.32 (95% CI: 3.84-53.44)。 这项研究证明中度至重度贫血和红细胞增多症与接受开颅脑肿瘤切除术的患者术后死亡率增加独立相关。这些发现强调了在开颅手术前识别和管理异常血细胞比容值的重要性。版权所有 © 2023 肖、程、贾、田、何、何、陈、浩、李、冲、海、尤、彭、方和张。

Abnormal hematocrit values, including anemia and polycythemia, are common in patients undergoing craniotomy, but the extent to which preoperative anemia or polycythemia independently increases the risk of mortality is unclear. This retrospective cohort study aimed to examine the association between preoperative anemia and polycythemia and postoperative mortality in patients who underwent craniotomy for brain tumor resection.We retrospectively analyzed data from 12,170 patients diagnosed with a brain tumor who underwent cranial surgery at West China Hospital between January 2011 and March 2021. The preoperative hematocrit value was defined as the last hematocrit value within 7 days before the operation, and patients were grouped according to the severity of their anemia or polycythemia. We assessed the primary outcome of 30-day postoperative mortality using logistic regression analysis adjusted for potential confounding factors.Multivariable logistic regression analysis reported that the 30-day mortality risk was raised with increasing severity of both anemia and polycythemia. Odds ratios for mild, moderate, and severe anemia were 1.12 (95% CI: 0.79-1.60), 1.66 (95% CI: 1.06-2.58), and 2.24 (95% CI: 0.99-5.06), respectively. Odds ratios for mild, moderate, and severe polycythemia were 1.40 (95% CI: 0.95-2.07), 2.81 (95% CI: 1.32-5.99), and 14.32 (95% CI: 3.84-53.44), respectively.This study demonstrated that moderate to severe anemia and polycythemia are independently associated with increased postoperative mortality in patients undergoing craniotomy for brain tumor resection. These findings underscore the importance of identifying and managing abnormal hematocrit values before craniotomy surgery.Copyright © 2023 Xiao, Cheng, Jia, Tian, He, He, Chen, Hao, Li, Chong, Hai, You, Peng, Fang and Zhang.