肌肉骨骼疾病 (MSD) 是影响身体骨骼、关节、肌肉、肌腱、韧带和神经的退行性疾病的集合。 MSD 影响着全球约 17.1 亿人，是导致残疾的重要原因。姜黄素是一种多酚化合物，具有抗炎、抗氧化和抗肿瘤特性。在这篇综述中，我们将讨论能够提高这种天然药物生物利用度的结构类似物、衍生物和纳米材料的研究进展。姜黄素可能会延缓骨质疏松症、骨关节炎和类风湿关节炎的进展。这些作用可能与姜黄素靶向多种信号通路有关。

Musculoskeletal disorders (MSD) are a collection of degenerative conditions impacting the body's bones, joints, muscles, tendons, ligaments, and nerves. MSDs affect approximately 1.71 billion individuals worldwide and are a significant cause of disability. Curcumin is a polyphenolic compound with anti-inflammatory, antioxidant, and antitumor properties. In this review, we will discuss the research progress of structural analogs, derivatives, and nanomaterials that can improve the bioavailability of this natural drug. Curcumin may potentially retard the progression of osteoporosis, osteoarthritis, and rheumatoid arthritis. These effects may be related to curcumin's targeting of multiple signalling pathways.