需要用安全和天然的纳米粒子来治疗癌细胞，以避免化疗药物的副作用。洋甘菊被认为是一种安全的天然植物，具有抗癌活性。我们使用洋甘菊 (CHM) 合成简单、廉价且环保的银纳米粒子 (SN)，以调节其抗癌特性。SN-CHM 是通过用 CHM 的水乙醇花提取物还原 100 mL 中的 1 mM 硝酸银水溶液来合成的（18 毫克/毫升，w/v）。反应在 600 rpm 和 28°C 下进行过夜。 SN-CHM 的特征包括产率百分比、平均直径、电荷、形态和银释放。此外，还分别研究了 200 µg/mL 和 5 mg/mL SN-CHM 的抗氧化和抗癌活性。产率 59.12%，SN-CHM 尺寸均一，为 115 ± 3.1 nm，ζ 电位为 -27.67观察到 ± (-3.92) mv。 CHM 和 SN-CHM 的紫外-可见光吸收分别从 379.5 nm 变化到 383.5 nm。此外，5小时后Ag最终从SN-CHM中释放出来。傅里叶变换红外光谱（FT-IR）显示CHM的特征吸收峰并产生SN-CHM。此外，SN-CHM 显示出中等的抗氧化活性。 20 μM SN-CHM 抑制 SW620 和 HT-29 细胞系的活力百分比。 SN-CHM 还可能极大地上调凋亡基因 BAX，同时显着下调抗凋亡基因 BCL2 和 BCL-Xl。CHM 可以是一种安全的软饮料，特别是当与银离子缀合作为抗癌纳米颗粒时。 SN-CHM 被认为对 SW620 和 HT-29 细胞系具有有效的抗癌活性。

There is a need to treat cancer cells with safe and natural nanoparticles to avoid the side effects of chemotherapeutic agents. Chamomile is considered a safe, natural plant with anticancer activity. We synthesize simple, inexpensive, and eco-friendly silver nanoparticles (SNs) using Chamomile (CHM) to tune their anticancer properties.SN-CHM was synthesized by reducing 1 mM silver nitrate aqueous solution in 100 mL with the aqueous ethanolic flower extract of CHM (18 mg/mL, w/v). The reaction proceeded overnight at 600 rpm and 28°C. SN-CHM was characterized for their % yield, average diameter, charge, morphology, and silver release. Moreover, SN-CHM was investigated for its antioxidant and anticancer activities at 200 µg/mL and 5 mg/ mL, respectively.A 59.12% yield and a uniform SN-CHM size of 115 ± 3.1 nm with a ζ-potential of -27.67 ± (-3.92) mv were observed. The UV-visible absorption showed shifts from 379.5 to 383.5 nm for CHM and SN-CHM, respectively. Moreover, Ag+ was ultimately released from SN-CHM after 5 h. Fourier Transform Infrared Spectroscopy (FT-IR) showed characteristic absorption peaks of CHM and produced SN-CHM. Furthermore, SN-CHM showed moderate antioxidant activity. SN-CHM inhibited the % viability of SW620 and HT-29 cell lines at 20 μM. SN-CHM may also greatly upregulate the apoptotic gene BAX while considerably downregulating the anti-apoptotic genes BCL2 and BCL-Xl.CHM can be a safe soft drink, especially when conjugated with Ag ions as anticancer NPs. SN-CHM is considered potent anticancer activity against SW620, and HT-29 cell lines.