肺癌（LC）带来了巨大的负担，并且与恶性肿瘤的高死亡率和发病率相关。特定 lncRNA 的异常表达与 LC 密切相关。 LncRNA 多态性导致表达水平异常和/或结构功能障碍。它们可以影响癌症患者的癌症进展、生存、化疗反应和复发率。本文全面概述了 lncRNA 遗传多态性对 LC 的影响。有人提出，lncRNA 相关变异可用于预测癌症风险和治疗结果。需要对不同种族群体进行更大规模的试验来验证结果，从而根据 lncRNA 基因型进行个性化 LC 治疗。

Lung cancer (LC) imposes a significant burden, and is associated with high mortality and morbidity among malignant tumors. Aberrant expression of particular lncRNAs is closely linked to LC. LncRNA polymorphisms cause abnormal expression levels and/or structural dysfunction. They can affect the progression of cancer, survival, response to chemotherapy and recurrence rates in cancer patients. The present article provides a comprehensive overview of the effect of lncRNA genetic polymorphisms on LC. It is proposed that lncRNA-related variants can be used to predict cancer risk and therapeutic outcomes. More large-scale trials on diverse ethnic groups are required to validate the results, thus personalizing LC therapy based on lncRNA genotypes.