卟啉基金属有机骨架材料（PMOFs）是一种晶体杂化材料，在能源、催化、生物医学等领域具有广阔的应用前景。在本研究中，使用卟啉配体和 La 离子构建了 La-TCPP PMOF 纳米晶体。该材料由于其特殊的多孔结构，可以对阿霉素（DOX）产生高负载率。药物分子的高负载率和卟啉配体的活性氧（ROS）使La-TCPP@DOX纳米晶在化疗（CT）和光动力疗法（PDT）的协同攻击下对癌细胞产生强大的杀伤作用。最后，通过对靶向适配体进行修饰，应用已建立的小鼠肿瘤模型证实了这种特殊La-TCPP@DOX@Apt材料对肿瘤的实际治疗效果。该复合纳米材料不仅避免了高浓度化疗药物带来的副作用，而且克服了PDT光穿透不足的局限性，在协同攻击的情况下能够抑制和杀伤实体瘤。这项研究是对PMOF晶体材料的补充，通过负载药物和引入靶向分子来实现其肿瘤杀伤能力，证明协同攻击可以更有效地抑制和治疗实体瘤。这些研究对于癌症患者的治疗具有参考和指导意义。

Porphyrin-based metal-organic frameworks (PMOFs) are a kind of crystal hybrid material with broad application prospects in energy, catalysis, biomedicine, and other fields. In this study, the La-TCPP PMOF nanocrystal was constructed using a porphyrin ligand and La ion. This material can produce a high loading rate on doxorubicin (DOX) owing to its special porous structure. The high loading rate of drug molecules and the reactive oxygen species (ROS) of the porphyrin ligand enable La-TCPP@DOX nanocrystal to produce a powerful killing effect on cancer cells under the synergistic attack of chemotherapy (CT) and photodynamic therapy (PDT). Finally, by modifying the targeted aptamer, the actual therapeutic effect of this special La-TCPP@DOX@Apt material on tumors was confirmed by applying the established mouse tumor model. The composite nanomaterial not only avoids the side effects caused by high concentrations of chemotherapeutic drugs, but also overcomes the limitation of PDT owing to insufficient light penetration and can inhibit and kill solid tumors under the condition of synergistic attack. This study is a complement to PMOF crystal materials, and its tumor-killing ability was achieved by loading drugs and introducing targeting molecules, which proves that the synergistic attack can more effectively inhibit and treat solid tumors. These studies have a reference and guiding significance for the treatment of cancer patients.