炎症和氧化应激在急性髓系白血病的发病机制中起着重要作用。髓过氧化物酶具有促氧化作用，而高密度脂蛋白胆固醇和对氧磷酶则具有抗氧化特性。因此，我们评估了急性髓系白血病病例的血清对氧磷酶、髓过氧化物酶和高密度脂蛋白胆固醇水平。测定了 40 名急性髓系白血病患者和 18 名健康个体的髓过氧化物酶、对氧磷酶和 HDL 胆固醇水平。研究了这些参数与其他预后因素之间的关系，以及它们与化疗反应的关系。与对照组相比，急性髓系白血病病例的髓过氧化物酶水平较高，而对氧磷酶和高密度脂蛋白胆固醇水平较低（分别为 p<<0.001、p<0.001、p=0.006）。髓过氧化物酶水平与对氧磷酶和HDL-c水平显着负相关（分别为r =  - 0.64，p < 0.001；r =  - 0.27，p = 0.02）。对氧磷酶水平与 HDL 水平呈正相关（r = 0.34，p = 0.04）。乳酸脱氢酶水平与HDL-c和对氧磷酶水平呈负相关，与髓过氧化物酶水平呈正相关（r =  - 0.37，p = 0.019；r =  - 0.35，p = 0.04；r = 0.45，p =分别 0.03）。完全缓解诱导治疗后，与其他病例相比，完全缓解病例的髓过氧化物酶水平较低，HDL-胆固醇和对氧磷酶水平较高（分别为p = 0.03、p = 0.01、p = 0.04）。急性髓性白血病病例中，髓过氧化物酶水平较高，而对氧磷酶和高密度脂蛋白胆固醇水平较低。获得的发现强调了炎症和氧化应激在急性髓系白血病发病机制中的潜在重要性。这些参数可用作预后预测和化疗反应预测的生物标志物。© 2023。作者获得 Springer Science Business Media, LLC（Springer Nature 旗下公司）的独家许可。

Inflammation and oxidative stress play a significant role in the pathogenesis of acute myeloid leukemia. While myeloperoxidase carries pro-oxidant effects, HDL-cholesterol and paraoxonase have antioxidant properties. Therefore, we evaluated serum paraoxonase, myeloperoxidase, and HDL-cholesterol levels in cases with acute myeloid leukemia. Myeloperoxidase, paraoxonase, and HDL-cholesterol levels in 40 acute myeloid leukemia patients and 18 healthy individuals were determined. The relationship between these parameters and other prognostic factors, as well as their association with response to chemotherapy, was investigated. Myeloperoxidase levels were higher, while paraoxonase and HDL-cholesterol levels were lower in acute myeloid leukemia cases compared to the control group (p < 0.001, p < 0.001, p = 0.006, respectively). The myeloperoxidase level was significantly negatively correlated with paraoxonase and HDL-c levels (r =  - 0.64, p < 0.001; r =  - 0.27, p = 0.02, respectively). Paraoxonase level was positively correlated with HDL level (r = 0.34, p = 0.04). Lactate dehydrogenase level was negatively correlated with HDL-c and paraoxonase levels and positively correlated with myeloperoxidase level (r =  - 0.37, p = 0.019; r =  - 0.35, p = 0.04; r = 0.45, p = 0.03, respectively). Following complete remission induction treatment, cases with complete remission had lower myeloperoxidase levels and higher HDL-cholesterol and paraoxonase levels compared to other cases (p = 0.03, p = 0.01, p = 0.04, respectively). Myeloperoxidase levels are higher, while paraoxonase and HDL-cholesterol levels are lower in acute myeloid leukemia cases. The obtained findings emphasize the potential importance of inflammation and oxidative stress in the pathogenesis of acute myeloid leukemia. These parameters can be used as biomarkers for prognosis prediction and prediction of response to chemotherapy.© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.