人乳头瘤病毒 (HPV) 被认为是导致许多器官中 95% 的病毒相关癌症的原因。口咽癌（OC）的特点是健康上皮细胞转化为癌前细胞。当前研究旨在检查口咽癌患者微阵列扫描的20个基因的基因表达不均匀。GSE56142数据集提取自Gene Expression国家生物技术信息中心综合；评估了 24 个样本。基因本体论 (GO)、京都基因和基因组百科全书以及蛋白质-蛋白质相互作用 (PPI) 用于使用各种软件来描述所研究基因的生物学作用。侵袭性 OC 患者中 20 个基因中有 6 个与高表达（PDGFRS、COL6A3、COL1A1、COL3A1、COL2A1 和 COL4A1）具有结合相关性，只有两个基因具有低表达（CRCT1 和 KRT78）。对 OC 患者与头颈鳞状细胞癌 (HNSCC) 患者的 20 个基因的表达水平进行了检查。 OC组高表达基因之间的相关系数具有统计学意义，P<0.05水平。特定基因的高表达水平可以作为诊断肿瘤标志物，特别是在癌症的早期阶段，应在OC组和OC组中进行检测。头颈部鳞癌患者。

Human papillomavirus (HPV) is considered to be responsible for 95% of virus-related cancers in many organs. Oropharyngeal carcinoma (OC) is distinguished by the transformation of the healthy epithelium into precancerous cells.The current study sought to examine the uneven gene expression of 20 genes among those scanned by microarray for oropharyngeal cancer patients.The GSE56142 dataset was extracted from the Gene Expression Omnibus of the National Center for Biotechnology Information; 24 specimens were evaluated. Gene ontology (GO), the Kyoto Encyclopedia of Genes and Genomes, and the protein-protein interaction (PPI) were used to depict the biological roles of the genes under investigation using types of software.Six genes out of 20 in patients with invasive OC had a binding correlation with high expression (PDGFRS, COL6A3, COL1A1, COL3A1, COL2A1, and COL4A1), and only two genes with low expression (CRCT1 and KRT78). The expression levels of 20 genes were examined for patients with OC versus head and neck squamous cell carcinoma (HNSCC). The correlation coefficient between highly expressed genes of the OC group was statistically significant at the P<0.05 level.High expression levels of specific genes may serve as diagnostic tumor markers, particularly in the early stages of cancer, and testing should be performed in OC and HNSCC patients.