背景和目的：最近的一份报告表明，局限于一个器官的寡转移（OGM）患者在立体定向身体放射治疗治愈后通常会发生其他身体器官的转移。本研究旨在确定接受常规治疗的脑转移瘤 (BRM) 患者的其他两个内脏器官 (TVO) 中存在转移性疾病是否与较差的预后相关。方法：这项回顾性临床调查包括 1996 年 5 月至 2020 年 2 月期间接受 OGM-BRM 姑息治疗的 26 名患者。这些患者根据 TVO 是否存在转移（13 名患者）或不存在转移（13 名患者）进行分类。结果：总体平均随访 16 个月，20 名患者死亡，6 名患者存活。 OGM-BRM-TVO 和非 OGM-BRM-TVO 亚型的中位生存期分别为 4 个月和 12 个月； 12 个月时相应的粗存活率为 0% 和 46% (p<0.01)。将预后与 BRM 数量（单个与多个）和 OGM-BRM 类别（同步与异时）相关联的亚组分析未能揭示有利于某个亚组的生存优势。结论：尽管证据是推测性的，但我们认为 OGM-BRM-TVO 患者更有可能出现侵袭性疾病。考虑到总体生存率较差的概念，我们建议针对这一特定患者群体采取更有针对性、危害较小或无害的管理方法（即姑息治疗或临终关怀）。

Background and Objective: A recent report indicated that metastases to other body organs commonly develop after stereotactic body radiation treatment for cure in patients with oligometastases (OGM) confined to one organ. This study was undertaken to determine if the presence of metastatic disease in two other visceral organs (TVO) in patients with conventionally treated brain metastases (BRM) was associated with poorer prognosis. Methods: This retrospective clinical investigation included 26 patients treated for palliation of OGM-BRM between May 1996 and February 2020. These individuals were classified according to the presence (13 patients) or absence (13 patients) of metastases in TVO. Results: With an overall mean follow-up of 16 months, 20 patients were deceased, and 6 patients were alive. The median survivals for the OGM-BRM-TVO and non-OGM-BRM-TVO subsets were 4 and 12 months, respectively; the corresponding crude survival rates at 12 months were 0% and 46% (p < 0.01). Subgroup analysis correlating prognosis to the number of BRM (single vs. multiple) and OGM-BRM categories (synchronous vs. metachronous) failed to reveal a survival advantage favoring a certain subgroup. Conclusion: Although the evidence is speculative, we believe that an aggressive disease condition is more likely present in patients with OGM-BRM-TVO. With the notion of an overall poor survival, we suggest a more tailored, less or nonharmful management approach (i.e., palliative therapy or hospice) for this particular patient cohort.