目的：雄激素剥夺疗法（ADT）可能会引起代谢结果、胰岛素敏感性、胰岛素样生长因子（IGF）和脂肪细胞衍生激素血清水平的不利变化。在这项预先计划的随机辅助研究中，我们旨在研究运动对抗局部晚期和转移性前列腺癌 (PCa) 男性由 ADT 引起的甘油三酯、胆固醇、腰围和胰岛素变化的能力。材料和方法：46 名接受治疗的 PCa 患者被随机分配接受为期 12 周、每周 180 分钟的无监督家庭运动游戏或常规护理。在基线以及 12 周和 24 周后测量血糖、血脂、胆固醇、脂联素、瘦素、胰岛素敏感性和胰岛素生长因子轴。使用线性混合效应模型分析从基线到第 24 周各组之间的差异。此外，在基线和 12 周/干预结束后测量血压、体重指数、体重和腰围并使用调整后的线性回归分析进行分析。结果：24周后，干预组和常规护理组之间血浆甘油三酯（差异：0.5mmol/L，P = 0.02）和高密度脂蛋白（HDL；差异：0.2mmol/L，P = 0.01）有利于干预组，而IGF结合蛋白-3（差异：148 μg/L，P = 0.01）有利于常规护理组。其余结果不受影响。结论：HDL 胆固醇的改善可以作为未来研究运动游戏心血管保护特性的随机对照试验的主要生物标志物。

Purpose: Androgen deprivation therapy (ADT) may induce unfavorable changes in metabolic outcomes, insulin sensitivity, insulin-like growth factors (IGFs), and in serum levels of adipocyte-derived hormones. In this preplanned randomized ancillary study, we aimed to investigate the ability of exercise to counteract alterations in triglyceride, cholesterol, waist circumference, and insulin caused by ADT in men with locally advanced and metastatic prostate cancer (PCa). Materials and Methods: Forty-six PCa patients undergoing treatment were randomized to 12 weeks of 180 minutes of weekly unsupervised home-based exergaming or usual care. Blood glucose, lipids, cholesterol, adiponectin, leptin, insulin sensitivity, and the insulin growth factor axis were measured at baseline, and after 12 and 24 weeks. Biomarkers were analyzed using a linear mixed-effect model of the difference between the groups from baseline to week 24. In addition, blood pressure, body mass index, body weight, and waist circumference were measured at baseline and after 12 weeks/end of intervention and analyzed using adjusted linear regression analysis. Results: After 24 weeks, a significant difference was seen between the intervention and usual care groups in plasma triglyceride (diff: 0.5 mmol/L, P = 0.02) and high-density lipoprotein (HDL; diff: 0.2 mmol/L, P = 0.01) favoring the intervention group, whereas IGF-binding protein-3 (diff: 148 μg/L, P = 0.01) favored the usual care group. The remaining outcomes were unaffected. Conclusion: Improvement in HDL cholesterol could be used as a primary biomarker in future randomized controlled trials investigating the cardiovascular protecting properties of exergaming.