细胞内脂质系统在各种生理功能和细胞生长过程中发挥着重要作用。然而，我们对该系统内复杂相互作用的理解，特别是线粒体和脂滴之间的相互作用，是有限的，特别是在癌细胞脂质代谢改变的背景下。为了解决这个问题，我们的研究引入了一种 N-B-O BODIPY-己基咔唑衍生物，名为 Cz-Boranil，它为可视化这些关键相互作用设定了新的基准。 Cz-Boranil 的独特功能在于其能够在正常细胞和癌细胞中显示出不同的细胞内分布模式，从而提供细致入微的细胞类型特异性分化。更令人印象深刻的是，该探针追踪了铁死亡和细胞凋亡的关键过程中脂滴和线粒体的协调相互作用。我们相信，Cz-Boranil 的创新能力将彻底改变我们对细胞内脂质相互作用的理解，并在识别和研究癌细胞方面发挥关键作用。版权所有 © 2023 Elsevier Inc. 保留所有权利。

Intracellular lipid systems play essential roles in various physiological functions and cell growth processes. However, our understanding of the intricate interactions within this system, especially between mitochondria and lipid droplets, is limited, particularly in the context of cancer cells' altered lipid metabolism. To address this, our study introduces an N-B-O BODIPY-hexylcarbazole derivative, named Cz-Boranil, that sets a new benchmark in visualizing these critical interactions. Cz-Boranil's unique capability lies in its ability to display distinct intracellular distribution patterns in both normal and cancer cells, offering nuanced cell type-specific differentiation. More impressively, this probe tracks the coordinated interactions of lipid droplets and mitochondria during the critical processes of ferroptosis and apoptosis. We believe that the innovative capabilities of Cz-Boranil will revolutionize our understanding of intracellular lipid interactions and prove pivotal in identifying and studying cancerous cells.Copyright © 2023 Elsevier Inc. All rights reserved.