在涂层石墨片 (GS) 基板 (N-CQD/GS) 上使用氮增强碳量子点 (N-CQD)，这是一种电化学检测人表皮生长因子受体 2 (HER2)（一种乳腺癌）的简单策略生物标志物，进行了研究。牛血清白蛋白 (BSA) 修饰的 HER2 抗体/N-CQDs/GS 免疫电极使生物传感器具有出色的活性保留，而 GS 电极提供了高度稳定的导电底物。线性响应范围为 0.1 ng/mL-1 ng/mL，检测下限为 4.8 pg/mL。同时，该方法证明了检测乳腺癌患者未经治疗的血液样本中 HER-2 蛋白的最佳特异性、稳定性和重现性。版权所有 © 2023 Elsevier B.V. 保留所有权利。

Using nitrogen-enhanced carbon quantum dots (N-CQDs) on a coated graphite sheet (GS) substrate (N-CQDs/GS), a simple strategy for the electrochemical detection of human epidermal growth factor receptor 2 (HER2), a breast cancer biomarker, was investigated. The bovine serum albumin (BSA)-modified HER2 Antibody/N-CQDs/GS immunoelectrode enabled excellent activity preservation for the biosensor, while the GS electrode provided a highly stable and conducting substrate. With a linear response range of 0.1 ng/mL-1 ng/mL and a low detection limit of 4.8 pg/mL. Meanwhile, the methodology demonstrated optimal specificity, stability, and reproducibility for detecting HER-2 protein in breast cancer patients untreated blood samples.Copyright © 2023 Elsevier B.V. All rights reserved.