决定肿瘤生长和转移的代谢可塑性现在被认为是癌症代谢中灵活且特定于环境的过程。促进真核细胞代谢适应的主要途径之一是自噬，这是一种细胞降解和回收过程，在饥饿或应激期间被激活，以维持代谢物和生物合成的中间水平。因此，肿瘤细胞的代谢适应能力与癌症中的自噬相关途径之间存在密切关联。此外，一氧化氮通过 S-亚硝基化调节蛋白质功能和信号传导，S-亚硝基化是一种翻译后修饰，也可以影响代谢和自噬。本综述的主要目的是提供 S-亚硝基化在癌症代谢和自噬交叉点中的作用的最新概述。首先，我们将概述 S-亚硝基化在肿瘤代谢适应中的参与。然后，我们将讨论自噬在癌症中的多方面作用、肿瘤进展过程中代谢与自噬之间的相互作用，以及 S-亚硝基化对癌症自噬失调的贡献。最后，我们将提出对相关治疗方面的见解并讨论未来的前景。版权所有 © 2023。由 Elsevier B.V. 出版。

Metabolic plasticity, which determines tumour growth and metastasis, is now understood to be a flexible and context-specific process in cancer metabolism. One of the major pathways contributing to metabolic adaptations in eucaryotic cells is autophagy, a cellular degradation and recycling process that is activated during periods of starvation or stress to maintain metabolite and biosynthetic intermediate levels. Consequently, there is a close association between the metabolic adaptive capacity of tumour cells and autophagy-related pathways in cancer. Additionally, nitric oxide regulates protein function and signalling through S-nitrosylation, a post-translational modification that can also impact metabolism and autophagy. The primary objective of this review is to provide an up-to-date overview of the role of S-nitrosylation at the intersection of metabolism and autophagy in cancer. First, we will outline the involvement of S-nitrosylation in the metabolic adaptations that occur in tumours. Then, we will discuss the multifaceted role of autophagy in cancer, the interplay between metabolism and autophagy during tumour progression, and the contribution of S-nitrosylation to autophagic dysregulation in cancer. Finally, we will present insights into relevant therapeutic aspects and discuss prospects for the future.Copyright © 2023. Published by Elsevier B.V.