为了在大型前瞻性队列中研究虚弱状态与老年发病 IBD 的长期风险之间的前瞻性关联。来自英国生物银行队列的参与者在入组时未患有 IBD 和癌症。通过 Fried 表型测量基线虚弱前和虚弱状态，包括体重减轻、疲惫、握力低、体力活动少和步行速度慢，定义为满足一项或两项标准以及满足三个或更多标准。主要结局是老年发病的 IBD，包括老年发病的溃疡性结肠炎 (UC) 和克罗恩病 (CD)。进行多变量 Cox 回归来检查相关关联。总共包括 417,253 名参与者（年龄 56.18±8.09​​ 岁）。其中，分别有 19,243 人（4.6%）和 188,219 人（45.1%）被认为是虚弱和处于虚弱状态。在中位 12.4 年的随访期间，发现了 1,503 例老年发病 IBD 病例（1001 例 UC、413 例 CD 和 89 例 IBD-未分类）。与非虚弱者相比，虚弱者（HR=1.40，95%CI：1.13-1.73）和虚弱前期（HR=1.15，1.03-1.28）个体在多变量调整后表现出老年发病IBD的风险显着更高（Ptrend< 0.001）。老年性 CD 风险的正相关性更为明显（体弱者 HR=2.16、1.49-3.13；体弱前期 HR=1.49、1.20-1.85；Ptrend<0.001）。根据年龄、性别和体重指数 (BMI) 进行的敏感性分析和亚组分析显示了相似的结果。虚弱和虚弱前期与老年发病 IBD（尤其是老年发病 CD）的风险增加相关。版权所有 © 2023 Elsevier Inc.保留权利。

To investigate the prospective association of frailty status with the long-term risk of elderly-onset IBD in a large prospective cohort.Participants free of IBD and cancer at enrollment from the UK Biobank cohort were included. Baseline pre-frail and frail status was measured by Fried phenotype including weight loss, exhaustion, low grip strength, low physical activity and slow walking pace, defined as meeting one or two criteria and meeting three or more criteria. Primary outcome was elderly-onset IBD, including elderly-onset ulcerative colitis (UC) and Crohn's disease (CD). Multivariable Cox regression was conducted to examine the related associations.Overall, 417,253 participants (aged 56.18±8.09 years) were included. Of whom, 19,243 (4.6%) and 188,219 (45.1%) were considered frail and pre-frail, respectively. During a median of 12.4 years follow-up, 1,503 elderly-onset IBD cases (1001 UC, 413 CD, and 89 IBD-Unclassified) were identified. Compared with non-frail, individuals with frail (HR=1.40, 95%CI: 1.13-1.73) and pre-frail (HR=1.15, 1.03-1.28) showed significantly higher risk of elderly-onset IBD after multivariable adjustment (Ptrend<0.001). The positive association was more evident regarding risk of elderly-onset CD (HR=2.16, 1.49-3.13 for frail; HR=1.49,1.20-1.85 for pre-frail; Ptrend<0.001). Sensitivity analyses and subgroup analyses according to age, gender and body mass index (BMI) demonstrated similar results.Frailty and pre-frailty are associated with increased risk of elderly-onset IBD, particularly elderly-onset CD.Copyright © 2023 Elsevier Inc. All rights reserved.