智能纳米粒子可以响应生物信号或受其引导，正在成为一种有前景的精确癌症治疗药物输送平台。肿瘤学、纳米技术和生物医学领域取得了快速进展，导致智能纳米粒子的创新发展，以实现更安全、更有效的癌症治疗。在这篇综述中，我们将重点介绍智能纳米颗粒的最新进展，包括聚合物纳米颗粒、树枝状聚合物、胶束、脂质体、蛋白质纳米颗粒、细胞膜纳米颗粒、介孔二氧化硅纳米颗粒、金纳米颗粒、氧化铁纳米颗粒、量子点、碳纳米管、黑磷、 MOF 纳米粒子等。我们将重点关注它们的分类、结构、综合和智能特征。这些智能纳米粒子具有响应各种外部和内部刺激的能力，例如酶、pH、温度、光学和磁性，使它们成为智能系统。此外，本综述还将探讨通过使用抗体、肽、转铁蛋白和叶酸等肿瘤特异性配体对智能纳米颗粒表面进行功能化来实现肿瘤靶向的最新研究。我们还将总结不同类型的药物递送方案，包括小分子、肽、蛋白质、核酸，甚至活细胞，以了解它们在癌症治疗中的潜在用途。虽然智能纳米粒子的潜力充满希望，但我们也将承认与其使用相关的挑战和临床前景。最后，我们将提出一个蓝图，涉及在癌症治疗应用中使用人工智能驱动的纳米颗粒。通过利用智能纳米粒子的潜力，本次综述旨在开创精确和个性化癌症治疗的新时代，为患者提供个性化的治疗选择。© 2023。作者。

Smart nanoparticles, which can respond to biological cues or be guided by them, are emerging as a promising drug delivery platform for precise cancer treatment. The field of oncology, nanotechnology, and biomedicine has witnessed rapid progress, leading to innovative developments in smart nanoparticles for safer and more effective cancer therapy. In this review, we will highlight recent advancements in smart nanoparticles, including polymeric nanoparticles, dendrimers, micelles, liposomes, protein nanoparticles, cell membrane nanoparticles, mesoporous silica nanoparticles, gold nanoparticles, iron oxide nanoparticles, quantum dots, carbon nanotubes, black phosphorus, MOF nanoparticles, and others. We will focus on their classification, structures, synthesis, and intelligent features. These smart nanoparticles possess the ability to respond to various external and internal stimuli, such as enzymes, pH, temperature, optics, and magnetism, making them intelligent systems. Additionally, this review will explore the latest studies on tumor targeting by functionalizing the surfaces of smart nanoparticles with tumor-specific ligands like antibodies, peptides, transferrin, and folic acid. We will also summarize different types of drug delivery options, including small molecules, peptides, proteins, nucleic acids, and even living cells, for their potential use in cancer therapy. While the potential of smart nanoparticles is promising, we will also acknowledge the challenges and clinical prospects associated with their use. Finally, we will propose a blueprint that involves the use of artificial intelligence-powered nanoparticles in cancer treatment applications. By harnessing the potential of smart nanoparticles, this review aims to usher in a new era of precise and personalized cancer therapy, providing patients with individualized treatment options.© 2023. The Author(s).