同型半胱氨酸 (Hcy)、可溶性溶基质素 2 (sST2) 和肿瘤相关癌抗原 125 (CA-125) 的血清水平与心力衰竭之间的关系需要进一步研究。本研究旨在评价充血性心力衰竭患者的Hcy、sST2、CA-125水平，并探讨其与心功能的相关性，为心力衰竭的临床诊断和治疗提供参考。 70例充血性心力衰竭患者2020 年 8 月至 2022 年 7 月期间诊断出的慢性心力衰竭 (CHF) 被分为心力衰竭 II 组 (n = 25)、III 组 (n = 23) 和 IV 组 (n = 22)。选择体检结果正常的70人作为健康组。对所有参与者的血清 Hcy、sST2 和 CA-125 水平进行了评估，并将其相互关联并与心功能分类相关。评估了单独的Hcy、sST2、CA-125水平以及这些因素的组合对CHF的诊断价值。健康组的Hcy、sST2和CA-125水平低于心力衰竭组。此外，在心力衰竭组 II、III 和 IV 中观察到 Hcy、sST2 和 CA-125 水平逐渐升高。个体 Hcy、sST2 和 CA-125 水平以及这些因素的组合与心功能分类显着相关 (p < 0.05)。 Hcy、sST2、CA-125水平均对CHF有诊断价值，三者联合诊断价值最佳。CHF患者Hcy、sST2、CA-125水平异常升高，且与心功能分级呈正相关。这些因素的个体水平，特别是三者的组合，对 CHF 诊断显示出良好的敏感性和特异性，可广泛应用于临床实践。

The relationships between serum levels of homocysteine (Hcy), soluble stromelysin 2 (sST2), and tumor-associated cancer antigen 125 (CA-125) and heart failure requires further investigation. The aim of the present study was to evaluate the levels of Hcy, sST2 and CA-125 in patients with congestive heart failure and to correlate these with cardiac function, thereby providing a reference for the clinical diagnosis and treatment of heart failure.Seventy patients with chronic heart failure (CHF) diagnosed between August 2020 and July 2022 were classified into heart failure groups II (n = 25), III (n = 23) and IV (n = 22). Seventy individuals with normal physical examination results were selected as the healthy group. Serum Hcy, sST2 and CA-125 levels for all participants were evaluated and correlated with each other and with cardiac function classification. The diagnostic value of individual Hcy, sST2, CA-125 levels for CHF was evaluated, as well as a combination of these factors.Hcy, sST2, and CA-125 levels were lower in the healthy group than in the heart failure group. Moreover, a progressive increase in Hcy, sST2, and CA-125 levels were observed in heart failure groups II, III, and IV. Individual Hcy, sST2 and CA-125 levels, as well as a combination of these factors, were significantly correlated with cardiac function classification (p < 0.05). Hcy, sST2 and CA-125 levels each showed diagnostic value for CHF, with the three combined having the best diagnostic value.Abnormally high levels of Hcy, sST2 and CA-125 occur in CHF patients and are positively correlated with cardiac function classification. Individual levels of these factors, and particularly a combination of the three, show good sensitivity and specificity for CHF diagnosis that could be widely used in clinical practice.