骨囊型包虫病诊治研究进展.
Progress of research on the diagnosis and treatment of bone cystic echinococcosis.
发表日期:2023
作者:
Yibin Meng, Qian Ren, Jun Xiao, Haohao Sun, Yiping Huang, Yaqing Liu, Shan Wang, Sibo Wang
来源:
Frontiers in Microbiology
摘要:
骨囊性包虫病 (CE) 是所有包虫病中最复杂、最危险的一种。该病缺乏典型的影像学特征和临床表现,给诊断和治疗带来困难。骨CE的X射线和计算机断层扫描(CT)图像与骨囊肿、巨细胞骨肿瘤和骨转移瘤相似,但磁共振成像(MRI)由于优异的软组织成像特征而显示出良好的诊断价值。由于交叉反应,血清学检测不能用作骨CE的明确诊断方法,这可能导致假阳性或假阴性结果。新抗原的开发可以开辟疾病诊断的新领域。目前,对于如何诊断和治疗骨CE,观点存在分歧。手术和药物治疗均可采用,但由于骨CE的部位和临床表现不同,很难确定哪种方法合适。大骨损伤不适合根治性切除,药物治疗变得很重要。本文综述骨CE的发病机制、临床表现、诊断策略和治疗方案的研究进展。我们的目的是为临床诊断和治疗方案提供参考。版权所有 © 2023 孟、任、肖、孙、黄、刘、王和王。
Bone cystic echinococcosis (CE) is one of the most complex and dangerous of all echinococcoses. The lack of typical imaging features and clinical manifestations makes diagnosis and treatment of this disease difficult. X-ray and computed tomography (CT) images of bone CE are similar to those of bone cysts, giant-cell bone tumors, and bone metastases, but magnetic resonance imaging (MRI) shows good diagnostic value due to excellent soft-tissue imaging features. Serological tests cannot be used as a definitive diagnostic method for bone CE due to cross-reactivity, which can lead to false-positive or false-negative results. The development of novel antigens can open new frontiers in the diagnosis of the disease. Currently, views conflict on how to diagnose and treat bone CE. Both surgical and pharmacological treatments can be used, but determining which is appropriate is difficult due to the different sites and clinical manifestations of bone CE. Radical resection is not indicated for large-bone injuries, and Pharmacotherapy becomes important. This article reviews the progress of research into the pathogenesis and clinical manifestations of, and diagnostic strategies and treatment options for, bone CE. We aimed to provide a reference for clinical diagnosis and -treatment options.Copyright © 2023 Meng, Ren, Xiao, Sun, Huang, Liu, Wang and Wang.