本研究详细介绍了与肺转移风险增加相关的四个因素：年龄、病理性骨折、局部复发和治疗方式。局部复发和病理性骨折是发生转移的独立危险因素。回顾性分析2016年1月至2021年12月在泰国孔敬医院治疗的50例诊断为骨巨细胞瘤（GCTB）的患者的数据。危险因素包括诊断时的年龄、GCTB 的位置、临床表现、Campanacci 分期和编号。使用单变量和多变量逻辑回归分析评估 GCTB 诱导的肺转移的局部复发率。在分析的 50 名患者中，9 名患者（18%）出现肺转移，平均年龄为 46.3 岁（范围为 18-68 岁）。本研究中没有患者死于肺转移。在转移的发生和临床骨折之间观察到统计学上显着的关联[比值比 (OR)，6.107； 95% 置信区间 (CI)，1.08-34.70] 和局部复发（OR，6.48；95% CI，1.03-40.87）。由于疾病进展的风险显着升高，同时出现临床骨折和局部肿瘤复发的患者需要更严格的临床观察。版权所有：© Poosiripinyo 等人。

The present study detailed four factors associated with an increased risk of pulmonary metastasis, age, pathological fracture, local recurrence and mode of treatment. Local recurrence and pathological fracture were independent risk factors for developing metastasis. From January 2016 to December 2021, data from 50 patients diagnosed with giant cell tumor of bone (GCTB) treated in Khon Kaen Hospital, Thailand, were retrospectively analyzed. The risk factors, including age at diagnosis, location of GCTB, clinical presentation, Campanacci stage and no. of local recurrences, for GCTB-induced pulmonary metastasis were evaluated using univariate and multivariable logistic regression analyses. Of the 50 patients analyzed, 9 patients (18%), with a mean age of 46.3 years (range, 18-68 years), developed pulmonary metastasis. No patients died from pulmonary metastasis in the present study. Statistically significant associations were observed between the development of metastasis and both clinical fracture [odds ratio (OR), 6.107; 95% confidence interval (CI), 1.08-34.70] and local recurrence (OR, 6.48; 95% CI, 1.03-40.87). Patients presenting with both a clinical fracture and local tumor recurrence require more rigorous clinical observation due to the significantly elevated risk of disease progression.Copyright: © Poosiripinyo et al.