环 GMP-AMP 合成酶 (cGAS) 被认为是细胞内的主要 DNA 传感器，具有识别外源 DNA 分子和游离 DNA 片段的能力。该识别过程通过干扰素基因激活剂 (STING) 促进 I 型干扰素的产生，该激活剂诱导下游转录因子的磷酸化。这一作用是 cGAS-STING 途径最典型的生物学功能的特征。当用抗肿瘤药物治疗时，细胞会经历 DNA 损伤，从而触发 cGAS-STING 通路的激活，最终导致 I 型 IFN 和相关下游干扰素刺激基因的表达。 cGAS-STING是重要的先天免疫通路之一，I型干扰素在先天免疫和T细胞抗肿瘤免疫之间的连接中发挥作用。I型干扰素促进肿瘤炎症细胞（包括NK细胞）的募集和激活I型干扰素还可以促进树突状细胞（DC）的活化和成熟，改善CD4 T淋巴细胞的抗原呈递，增强CD8 T淋巴细胞的交叉呈递，从而上调抗肿瘤反应。本文讨论了 cGAS-STING 信号传导及其在传统肿瘤治疗和免疫治疗中的机制和生物学功能。版权所有 © 2023 Wang、Lin、Zhu 和 Ye。

Cyclic GMP-AMP synthetase (cGAS), recognized as the primary DNA sensor within cells, possesses the capability to identify foreign DNA molecules along with free DNA fragments. This identification process facilitates the production of type I IFNs through the activator of the interferon gene (STING) which induces the phosphorylation of downstream transcription factors. This action characterizes the most archetypal biological functionality of the cGAS-STING pathway. When treated with anti-tumor agents, cells experience DNA damage that triggers activation of the cGAS-STING pathway, culminating in the expression of type I IFNs and associated downstream interferon-stimulated genes. cGAS-STING is one of the important innate immune pathways,the role of type I IFNs in the articulation between innate immunity and T-cell antitumour immunity.type I IFNs promote the recruitment and activation of inflammatory cells (including NK cells) at the tumor site.Type I IFNs also can promote the activation and maturation of dendritic cel(DC), improve the antigen presentation of CD4+T lymphocytes, and enhance the cross-presentation of CD8+T lymphocytes to upregulating anti-tumor responses. This review discussed the cGAS-STING signaling and its mechanism and biological function in traditional tumor therapy and immunotherapy.Copyright © 2023 Wang, Lin, Zhu and Ye.