研究动态
Articles below are published ahead of final publication in an issue. Please cite articles in the following format: authors, (year), title, journal, DOI.

用于成像引导结直肠癌光热治疗的纳米颗粒。

Nanoparticles for imaging-guided photothermal therapy of colorectal cancer.

发表日期:2023 Nov
作者: Omid Rahbar Farzam, Niloofar Mehran, Farzaneh Bilan, Ehsan Aghajani, Reza Dabbaghipour, Ghazale Asemani Shahgoli, Behzad Baradaran
来源: PHYSICAL THERAPY & REHABILITATION JOURNAL

摘要:

结直肠癌(CRC)是全球最常见的恶性肿瘤之一,死亡率很高。虽然手术、化疗和放疗在提高生存率方面显示出一定的效果,但它们也存在副作用和对健康组织造成伤害等缺点。治疗诊断方法整合了癌症诊断和治疗的过程,可以最大限度地减少生物副作用。光热疗法(PTT)是一种新兴的治疗方法,利用光敏剂在肿瘤部位产生热量并引起热侵蚀。使用成像引导 PTT 治疗 CRC 的纳米技术的发展取得了重大进展。具有合适物理和化学性质的纳米颗粒可以提高癌症诊断和PTT的效率。这种方法能够监测癌症治疗进展并保护健康组织。在本文中,我们简要介绍了金属纳米颗粒、聚合物纳米颗粒和碳纳米颗粒在成像引导结直肠癌PTT中的应用。© 2023 作者。由爱思唯尔有限公司出版
Colorectal cancer (CRC) is one of the most common malignancies with a high mortality rate worldwide. While surgery, chemotherapy, and radiotherapy have shown some effectiveness in improving survival rates, they come with drawbacks such as side effects and harm to healthy tissues. The theranostic approach, which integrates the processes of cancer diagnosis and treatment, can minimize biological side effects. Photothermal therapy (PTT) is an emerging treatment method that usages light-sensitive agents to generate heat at the tumor site and induce thermal erosion. The development of nanotechnology for CRC treatment using imaging-guided PTT has garnered significant. Nanoparticles with suitable physical and chemical properties can enhance the efficiency of cancer diagnosis and PTT. This approach enables the monitoring of cancer treatment progress and safeguards healthy tissues. In this article, we concisely introduce the application of metal nanoparticles, polymeric nanoparticles, and carbon nanoparticles in imaging-guided PTT of colorectal cancer.© 2023 The Authors. Published by Elsevier Ltd.