肝损伤是一种普遍的病理过程，可导致脂肪肝、肝硬化、纤维化甚至癌症等疾病。据观察，植物和天然产物对肝损伤具有显着的保护作用。目前的研究旨在探讨杏仁壳对大鼠模型中四氯化碳 (CCl4) 诱导的肝毒性的功效。由于杏仁壳含有多种酚类和黄酮类化合物，这些化合物在很大程度上与抗氧化和保肝特性有关。为此，对 20 种植物提取物的小规模文库进行了筛选，通过 DPPH 测定评估抗氧化潜力。数据显示，杏仁壳提取物 (ASEE) 表现出有效的抗氧化活性。在 30 只大鼠体内模型中进一步评估了这种有效提取物的保肝活性，大鼠模型分为 6 组，每组 5 只。第29天处死所有大鼠并收集血清用于进一步分析。肝组织也保存在福尔马林中用于组织病理学。结果表明，与 CCl4 组相比，ASEE 对肝功能测试 (LFT)、肾功能测试 (RFT) 和脂质生物标志物显示出保护作用。组织学数据还揭示了对肝损伤的重大保护作用，其特征是细胞凋亡减少、肝出血减少和细胞碎片积累减少。数据表明，杏仁壳乙醇提取物具有保肝潜力，表明其在临床前研究后作为保肝药物开发的替代来源的可行性。© 2023 作者。

Liver injury is a prevalent pathological process that can give rise to conditions such as fatty liver, cirrhosis, fibrosis, and even cancer. It has been observed that plants and natural products possess significant protective effects against liver injury. Current study was performed to investigate the efficacy of almonds shell against carbon tetrachloride (CCl4) induced hepatotoxicity in rat model. As almonds shell contain a large variety of phenolic and flavonoid compounds, which are largely associated with antioxidant and hepatoprotective properties. For this purpose, screening of small-scale library of twenty plant extracts was performed for evaluation of antioxidant potential by DPPH assay. The data revealed that almonds shell extract (ASEE) exhibited potent antioxidant activity. This potent extract was further evaluated for hepatoprotective activity in in vivo rat model on 30 rats, divided into 6 groups of 5 rats each. On 29th day all rats were sacrificed and blood serum was collected for further analysis. Liver tissues were also preserved in formalin for histopathology. The results demonstrated that ASEE displayed a protective effect on liver function tests (LFT), renal function tests (RFT), and lipid biomarkers in comparison to the CCl4 group. The histological data also unveiled a substantial safeguarding impact on liver damage, characterized by a reduction in apoptosis, diminished liver hemorrhage, and decreased accumulation of cellular debris. The data indicates that ethanolic extract from almond shells possesses hepatoprotective potential, suggesting its viability as an alternative source for hepatoprotective drug development after pre-clinical research.© 2023 The Authors.