解旋酶 POLQ 样（HELQ 或 Hel308）是一种高度保守的 3'‑5' 超家族 II DNA 解旋酶，有助于多种 DNA 过程，包括 DNA 修复、解旋和链退火。 HELQ 缺陷在生殖细胞稳定性中发挥着关键作用，因此会导致生育能力低下。此外，在多种肿瘤中观察到HELQ的异常表达，并且许多分子通路，包括核苷酸切除修复、检查点激酶1-DNA修复蛋白RAD51同源物1和ATM/ATR通路，已被证明参与参与HELQ。在本综述中，描述了 HELQ 的结构和特征，以及它在 DNA 加工中的主要功能。还描述了肿瘤发生过程中涉及 HELQ 的分子机制。据推测，HELQ 生物学值得研究，并且其在调节各种 DNA 过程和参与肿瘤发生中的关键作用具有临床相关性。

Helicase POLQ‑like (HELQ or Hel308), is a highly conserved, 3'‑5' superfamily II DNA helicase that contributes to diverse DNA processes, including DNA repair, unwinding, and strand annealing. HELQ deficiency leads to subfertility, due to its critical role in germ cell stability. In addition, the abnormal expression of HELQ has been observed in multiple tumors and a number of molecular pathways, including the nucleotide excision repair, checkpoint kinase 1‑DNA repair protein RAD51 homolog 1 and ATM/ATR pathways, have been shown to be involved in HELQ. In the present review, the structure and characteristics of HELQ, as well as its major functions in DNA processing, were described. Molecular mechanisms involving HELQ in the context of tumorigenesis were also described. It was deduced that HELQ biology warrants investigation, and that its critical roles in the regulation of various DNA processes and participation in tumorigenesis are clinically relevant.