金雀异黄素 (GEN) 是多酚家族的一员，主要以其对代谢疾病和妇科疾病的作用而闻名。 GEN通过抑制肿瘤增殖、肿瘤转移、侵袭、迁移和诱导细胞凋亡而具有抗癌特性。卵巢癌（OC）在最常见的妇科癌症中排名第七。尽管与其他癌症相比其发病率较低，但它却是妇科恶性肿瘤中的首位死因。手术和化疗是治疗这种致命癌症的主要选择。因此，对 GEN 的进一步研究可能有助于发现预防和/或治疗 OC 的新疗法。在这篇综述中，我们旨在研究 GEN 在卵巢癌中的作用。我们研究了 GEN 对 OC 细胞系的抗肿瘤作用，包括诱导细胞凋亡、抑制肿瘤生长和抑制转移。此外，我们还回顾了调查 GEN 在其他化疗药物（例如顺铂、槲皮素和吉西他滨）治疗方案中作为佐剂作用的研究。版权所有 © Bentham Science Publishers；如有任何疑问，请发送电子邮件至 epub@benthamscience.net。

Genistein (GEN) is a member of the polyphenol family, known chiefly for its effects on metabolic diseases and gynecological disorders. GEN has anti-cancer properties by inhibiting tumor proliferation, tumor metastasis, invasion, migration, and inducing apoptosis. Ovarian cancer (OC) is ranked 7th among the most common gynecological cancers. Despite its low incidence compared to other cancers, it is the first cause of death among gynecologic malignancies. Surgery and chemotherapy are the main options for treating this fatal cancer. Therefore, further investigations into GEN may aid in the discovery of novel therapeutics for preventing and/or treating OC. In this review, we aim to investigate the role of GEN in ovarian cancer. We investigate the anti-tumor effects of GEN on OC cell lines, including inducing apoptosis, suppressing tumor growth, and inhibiting metastasis. Also, we review the studies investigating GEN's roles as an adjuvant in therapeutic regimens with other chemotherapeutic agents (e.g., cisplatin, quercetin, and gemcitabine).Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.