G 蛋白偶联雌激素受体 (GPER) 1 介导非基因组雌激素相关信号传导，并通过多种下游途径在调节细胞生长和程序性细胞死亡中发挥重要作用。尽管人们对 GPER1 在癌症发展中的作用越来越感兴趣，但尚未对 GPER1 进行泛癌分析。在本研究中，我们通过人类蛋白质图谱 (HPA) 对 GPER1 在泛癌中的作用进行了全面分析，癌症基因组图谱 (TCGA)、加州大学圣克鲁斯分校 Xena (UCSC XENA)、基因型组织表达 (GTEx)、MethSurv、阿拉巴马大学伯明翰分校 CANcer 数据分析门户 (UALCAN)、cBioPortal、STRING 和 TISIDB 数据库， GPER1在组织器官中广泛表达，在多种癌症中与正常组织表达存在差异。在诊断评估中，九种癌症类型的曲线下面积 (AUC) 超过 0.9。生存分析显示 GPER1 与 11 种癌症类型的预后相关。此外，GPER1表达与多种癌症中的免疫浸润相关。总之，GPER1在各种恶性肿瘤中具有良好的诊断或预后价值。结合其与免疫成分的广泛相关性，上述结果表明GPER1在肿瘤诊断和预后方面显示出良好的前景，为精准、个性化的抗肿瘤策略提供了新思路。

The G protein-coupled oestrogen receptor (GPER) 1 mediates non-genomic oestrogen-related signalling and plays an important role in the regulation of cell growth and programmed cell death through multiple downstream pathways. Despite the increasing interest in the role of GPER1 in cancer development, no pan-cancer analysis has been available for GPER1.In this study we performed a comprehensive analysis of the role of GPER1 in pan-cancer via Human Protein Atlas (HPA), The Cancer Genome Atlas (TCGA), University of California, Santa Cruz Xena (UCSC XENA), Genotype-Tissue Expression (GTEx), MethSurv, The University of Alabama at Birmingham CANcer data analysis Portal (UALCAN), cBioPortal, STRING and TISIDB detabases, followed by enrichment analysis using R software.GPER1 was widely expressed in tissues and organs and differed in expression from normal tissue in a variety of cancers. In diagnostic assessment, it's Area Under the Curve (AUC) surpassed 0.9 in nine cancer types. Survival analysis showed that GPER1 was correlated with the prognosis of 11 cancer types. Moreover, GPER1 expression was associated with immune infiltration in multiple cancers.In summary, GPER1 has good diagnostic or prognostic value across various malignancies. Together with its extensive correlation with immune components, the aforementioned results suggests that GPER1 shows promise in tumour diagnosis and prognosis, providing new ideas for precise and personalised anti-tumour strategies.